laryngopharyngeal reflux/asthenia

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Role of Matrix Metalloproteinases 7 in the Pathogenesis of Laryngopharyngeal Reflux: Decreased E-cadherin in Acid exposed Primary Human Pharyngeal Epithelial Cells.

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Cleavage of E-cadherin and the resultant weakness in the cell-cell links in the laryngeal epithelium lining is induced by exposure to acidic contents of the refluxate. Herein, we aimed to evaluate the role of matrix metalloproteinases (MMPs) in inducing E-cadherin level changes following acid

Perceptual, Aerodynamic, and Acoustic Characteristics of Voice Changes in Patients with Laryngopharyngeal Reflux Disease.

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Laryngopharyngeal reflux (LPR) is an inflammatory condition suspected to be associated with dysphonia. In this study, we investigated multidimensional perceptual, aerodynamic, and acoustic voice changes in patients with clinically diagnosed LPR compared to healthy participants. We prospectively

[Therapeutic effect of acid-suppressing therapy combined with voice therapy in patients with voice-related symptoms caused by laryngopharyngeal reflux].

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Objective:Patients with laryngopharyngeal reflux frequently experience voice-related symptoms. This was a prospective study that designed to investigate the effectiveness of combined voice and medical therapy in comparison with medical therapy alone in the improvement of voice-related

Voice Quality as Therapeutic Outcome in Laryngopharyngeal Reflux Disease: A Prospective Cohort Study.

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OBJECTIVE To study the usefulness of voice quality as therapeutic outcome in laryngopharyngeal reflux disease. METHODS A total of 80 patients with reflux finding score (RFS) > 7 and reflux symptom index (RSI) > 13 were treated with pantoprazole, diet, and lifestyle recommendations for 3 months. The

Combination of voice therapy and antireflux therapy rapidly recovers voice-related symptoms in laryngopharyngeal reflux patients.

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OBJECTIVE Patients with laryngopharyngeal reflux frequently experience voice-related symptoms. This study was designed to investigate the effectiveness of combined voice and medical therapy in comparison with medical therapy alone in the improvement of voice-related symptoms and parameters in

Impact of laryngopharyngeal reflux on subjective and objective voice assessments: a prospective study.

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BACKGROUND Laryngopharyngeal reflux is a prevalent, not well-understood disease affecting a high proportion of patients who seek laryngology consultation. The objective of this prospective case series is to explore the subjective and objective voice modifications in Laryngopharyngeal reflux (LPR),

Instruments evaluating the clinical findings of laryngopharyngeal reflux: A systematic review.

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OBJECTIVE To identify the instruments for evaluating the clinical findings (ICFs) of laryngopharyngeal reflux (LPR) designed for use with regard to diagnosis and treatment effectiveness. METHODS The PubMed, Scopus, and Cochrane databases were used to search for subject headings following Preferred

Impact of Laryngopharyngeal Reflux on Subjective, Aerodynamic, and Acoustic Voice Assessments of Responder and Nonresponder Patients.

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OBJECTIVE To investigate the usefulness of voice quality assessment as a treatment outcome in responder and nonresponder patients with laryngopharyngeal reflux (LPR). METHODS Eighty clinically diagnosed LPR patients with reflux finding score (RFS) > 7 and reflux symptom index (RSI) > 13 were treated

Gender differences in the presentation of dysphonia related to laryngopharyngeal reflux disease: a case-control study.

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OBJECTIVE To investigate the voice quality impairments in patients with laryngopharyngeal reflux (LPR) according to the gender. METHODS Controlled multi-center study. METHODS 80 LPR patients (40 males and 40 females) with reflux finding score (RFS) > 7 and reflux symptom index (RSI) > 13 were

Change of signs, symptoms and voice quality evaluations throughout a 3- to 6-month empirical treatment for laryngopharyngeal reflux disease.

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OBJECTIVE To assess the usefulness of voice quality measurements as a treatment outcome in patients with laryngopharyngeal reflux (LPR)-related symptoms. METHODS Prospective uncontrolled multi-centre study. METHODS A total of 80 clinically diagnosed LPR patients with a reflux finding score (RFS)>7

Persistent dysphonia after laryngomicrosurgery for benign vocal fold disease.

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OBJECTIVE Laryngomicrosurgery (LMS) is used to manage most vocal fold lesions. However, the functional voice outcome of the LMS might be diverse due to the influence of various factors. We intend to evaluate the incidence and etiologic factors of persistent dysphonia after LMS for benign vocal fold

Is a voice-specific instrument more indicative of stroboscopy results than common clinical queries?

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To determine whether the Voice Handicap Index-10 (VHI-10) predicts diagnoses made via laryngoscopy/stroboscopy, as compared to common clinical inquiries about vocal characteristics.We prospectively collected data from a cohort of 204 consecutive patients

Rapidly worsening bulbar symptoms in a patient with spinobulbar muscular atrophy.

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X-linked spinobulbar muscular atrophy (Kennedy's disease) affects muscles and motor neurons, manifesting as weakness and wasting of bulbar, facial, and proximal limb muscles due to loss of anterior horn cells in the brain and spinal cord. We present the case of a patient with X-linked spinobulbar

Laryngeal and vocal evaluation in untreated growth hormone deficient adults.

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OBJECTIVE To evaluate the consequences of lifetime, severe and untreated isolated growth hormone deficiency (IGHD) on vocal and laryngeal function. METHODS Cross-sectional. METHODS A total of 23 IGHD adult subjects and 22 controls were administered a questionnaire about vocal complaints and harmful

The Effect of the Speech Task Characteristics on Perceptual Judgment of Mild to Moderate Dysphonia: A Methodological Study.

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OBJECTIVE To study the differences in perceptual ratings of mild and moderate dysphonia related to the speech task, and their impact on intrarater and interrater reliabilities. METHODS Voice recordings of 15 outpatients with mild or moderate dysphonia related to laryngopharyngeal reflux were

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