optimel manuka eyedrops 10 ml used as directed in a CAC (Conjunctival allergen challenge) study

sterile normal saline eyedrops used as directed in a CAC (conjunctival allergen challenge) study

Allergic Conjunctivitis

manuka eyedrops applied to the ocular surface

Manuka honey

Toyos Clinic

Manuka Eye Droops for Treatment of Allergy

A Phase 4 Study to Assess the Clinical Efficacy and Safety of Manuka Eye Drops for Treatment of Allergy

on a scale from 0-100 where 0 =no itching and 100=maximal itching subtracted scores measured for placebo treatments at visits 3B, 4 and 5

on a scale from 0-100 where 0=no hyperemia and 100=maximal hyperemia subtracted scores from placebo treatments at visits 3B, 4 and 5

If requested, data records without identifying patient information could be shared

randomized, double-blind placebo controlled

medications will be covered by blank labels

Patients with a stage III pressure ulcer who are randomized into this arm will be given standard treatment (hydrogel, collegense, and silver alginate dressings).

Patients with a stage III pressure ulcer who are randomized into this treatment arm will be given leptospermum scoparium honey dressings for treatment of their wound.

Patients with a stage IV pressure ulcer who are randomized into this arm will be given standard treatment (hydrogel, collegense, and silver alginate dressings).

Patients with a stage IV pressure ulcer who are randomized into this treatment arm will be given leptospermum scoparium honey dressings for treatment of their wound.

Pressure Ulcers

No information available- PI left- study being withdrawn.

Leptospermum scoparium honey

Standard of Care Treatment

NYC Health + Hospitals/Coney Island

Leptospermum Scoparium Honey and Wound Care for Pressure Ulcers

Developed by the National Pressure Ulcer Advisory Panel (NPUAP) as a quick and reliable tool to monitor the change in pressure ulcer status over time and has been incorporated as a standard assessment tool in acute care settings.

Observed by staff and patient, will be scored as no odor, odor on dressing change, odor all the time.

Presence or absence of irritation as determined by clinical observation

Pain in and around pressure ulcer assessed by tenderness to the touch by clinician (recorded as present or absent)

New York City Health and Hospitals Corporation

Study patients diagnosed with acute pouchitis after bowel surgery for ulcerative colitis will perform manuka honey enemas twice a day for 30 days.

Pouchitis

Study patients diagnosed with acute pouchitis will perform manuka honey enemas twice a day for 30 days.

Manuka honey enema

Saint Paul's Hospital

To Determine the Effect of Honey Enema in the Treatment of Patients With Acute Pouchitis

To Determine the Effect of Honey Enema in the Treatment of Patients With Acute Pouchitis (Pilot Study)

PDAI score is a criterion for defining pouchitis. A PDAI score will be calculated from a proctoscopy assessment before treatment. Within two weeks after the treatment, another proctoscopy will be performed to determine the post-treatment PDAI score to see if there is a decrease in PDAI score for the study patients.

includes stool frequency (no different, 1-2 stools/day > postoperative usual, 3 or more stools/day > postoperative usual), rectal bleeding (none or rare or present daily), fecal urgency or abdominal cramps (none, occasional or usual), presence of fever (temperature >37.8° C), abdominal pain (no, occasional or usual) and readmission to hospital for any reason.

Dr. Carl J Brown

Head, Division of General Surgery, clinical assistant professor of surgery at University of British Columbia

Canadian Association of General Surgeons

Pea-sized amount of tea tree oil medicated gel (containing 200mg/g tea tree oil) applied to the face twice daily for 12 weeks.

Acne

Tea tree oil

Royal Perth Hospital

Hollywood Private Hospital

Pilot Study to Evaluate Tea Tree Oil Gel for Facial Acne

Uncontrolled, Open-label, Phase II Pilot Study to Evaluate the Efficacy, Tolerability and Acceptability of 200mg/g Tea Tree Oil Gel Applied Topically Twice Daily for the Treatment of Mild to Moderate Facial Acne

Numbers of inflamed and non-inflamed facial lesions will be counted.

A 5-point severity scale (0-4) will be used to give an overall acne grade.
0: Clear skin with no lesions
Almost clear; rare lesions
Mild severity; some non-inflammatory lesions with no more than a few inflammatory lesions
Moderate severity; up to many non-inflammatory lesions and may have some inflammatory lesions
Severe; up to many noninflammatory and inflammatory lesions but no more than a few nodular lesions

Decrease in numbers of non-inflammatory lesions from baseline

Decrease in inflammatory lesion count from baseline

Decrease in perceived facial oiliness from baseline

Mean tolerability will be determined as the average of the following;
Erythema
Scaling
Peeling
Burning
Induration
Dryness
These six parameters will be measured using a 5-point scale (0: None, 1: Minimal, 2: Mild, 3: Moderate, 4: Severe). Mean tolerability will be the average of these scores.

Any local or systemic adverse events will be recorded including the type of reaction and severity (on a 5-point severity scale where 0 = none and 4 = severe).

Katherine Hammer

Research Assistant Professor

The University of Western Australia

Saline Nasal Irrigation is actively being used as the standard of care. It does not contain any active ingredients.

Manuka Honey Irrigation involves the experimental treatment of manuka honey nasal irrigation.

Sinusitis

The use of the nasal irrigation on post-operative day #1. 30mL of the nasal irrigation will be applied to each nostril by a 60mL Toomey syringe (given to patient at pre-operative clinic visit) twice a day (once in am, once in pm). This will continue until the 6 month post-op visit.

Manuka Honey

Saline Irrigation

ENT Clinic, St. Paul's Hospital

Manuka Honey Irrigation After Sinus Surgery

Manuka Honey Irrigation After Endoscopic Sinus Surgery

Sino-Nasal Outcome Test (SNOT-22) is current standard in Rhinology for the assessment of the patient's subjective sinus symptoms and its effect on their daily functioning. It is composed of 22 questions, which ask patients to rate their symptoms on a scale of 0-5 (0=no problem, 5=problem as bad as it can be). Questions include patients perceived nasal congestion/blockage, facial pain, fatigue, sadness, etc. This questionnaire is used as the gold standard for patients to rate their subjective symptoms.

leptospermum brachyandrum/hypersensitivity

Manuka Eye Droops for Treatment of Allergy

Leptospermum Scoparium Honey and Wound Care for Pressure Ulcers

To Determine the Effect of Honey Enema in the Treatment of Patients With Acute Pouchitis

Pilot Study to Evaluate Tea Tree Oil Gel for Facial Acne

Manuka Honey Irrigation After Sinus Surgery

Baz done ki pi konplè remèd fèy medsin te apiye nan syans