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linum narbonense/justicidin
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Linum narbonense: A new valuable tool for biotechnological production of a potent anticancer lignan Justicidine B.
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Log In / Enskri
BACKGROUND
Arylnaphthalene lignan Justicidin B is a lead compound in the management of bone cancer and osteoclastogenesis. The compound is the main cytotoxic principle of rare medicinal plant Linum narbonense L. (Linaceae). However, there have been no reports on the bioreactor production of
Cytotoxic activity of extracts from Linum cell cultures.
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Log In / Enskri
Callus and suspension cultures of Linum narbonense and Linum leonii were developed to study the production of lignans and their cytotoxic activity. Justicidin B was determined to be the main lignan. The maximal yield of justicidin B up to 2.22 mg/g of the cell dry weight was detected in the callus
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