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Experiments indicate that several different calcium antagonists have vasodilatory properties which may be expressed selectively on different organ vascular beds. Verapamil was most active as a vasodilator in muscular microvasculature. Cerebral venules are most sensitive to nimodipine. Nisoldipine is
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Although barbiturates are often effective as therapeutic agents in several types of brain ischemia, there is no consensus as to their mechanisms of action. Exactly why other intravenous anesthetics such as ketamine are not effective therapies in brain ischemia is not known. Structural analogs of
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