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A novel small molecule liver X receptor transcriptional regulator, nagilactone B, suppresses atherosclerosis in apoE-deficient mice.
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Atherosclerosis is the most common cause of cardiovascular diseases, such as myocardial infarction and stroke. We hypothesized that nagilactone B (NLB), a small molecule extracted from the root bark of Podocarpus nagi (Podocarpaceae), suppresses atherosclerosis in an atherosclerotic mouse
Function in elderly cancer survivors depends on comorbidities.
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BACKGROUND
Factors associated with functional status in elderly cancer survivors, in particular, comorbidity, have been inadequately studied.
METHODS
Of 4162 participants aged 65 and older enrolled in the Duke Established Populations for Epidemiologic Studies of the Elderly study in 1986, 376 of the
A longitudinal study of parkinsonism and disability in a community population of older people.
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BACKGROUND
Parkinsonian signs in patients without Parkinson's disease are often undetected but occur frequently in older people, and are often considered benign. We measured the association between parkinsonism and subsequent disability.
METHODS
We conducted a prospective, longitudinal,
Association between concurrent and remote blood pressure and disability in older adults.
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The objective of this study was to investigate the association between blood pressure and disability in older adults. Stroke-free participants in the Charleston Heart Study (n=999, mean age=68.5+/- 0.2 years SE, 57% women, and 39% African Americans) were followed between 1960 and 1993. Functional
Age, functional status, and racial differences in plasma D-dimer levels in community-dwelling elderly persons.
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BACKGROUND
Dysregulation of immunologic and coagulation systems is common in elderly persons and is associated with many diseases of aging. Thrombotic events are a major cause of morbidity and mortality in the elderly population. This study assesses whether D-dimer, a marker of fibrinolytic
Characteristics of physical measurement consent in a population-based survey of older adults.
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BACKGROUND
Collecting physical measurements in population-based health surveys has increased in recent years, yet little is known about the characteristics of those who consent to these measurements.
OBJECTIVE
To examine the characteristics of persons who consent to physical measurements across
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