nagilactone/podocarpus

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A novel small molecule liver X receptor transcriptional regulator, nagilactone B, suppresses atherosclerosis in apoE-deficient mice.

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Atherosclerosis is the most common cause of cardiovascular diseases, such as myocardial infarction and stroke. We hypothesized that nagilactone B (NLB), a small molecule extracted from the root bark of Podocarpus nagi (Podocarpaceae), suppresses atherosclerosis in an atherosclerotic mouse

Nagilactone D ameliorates experimental pulmonary fibrosis in vitro and in vivo via modulating TGF-β/Smad signaling pathway.

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Pulmonary fibrosis is a prototypic chronic progressive lung disease with high morbidity and mortality worldwide. Novel effective therapeutic agents are urgently needed owing to the limited treatment options in clinic. Herein, nagilactone D (NLD), a natural norditerpenoid obtained from Podocarpus

Combination effects of antifungal nagilactones against Candida albicans and two other fungi with phenylpropanoids.

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Antifungal activity of three nagilactones isolated from the root bark of Podocarpus nagi (Podocarpaceae), alone and in combination with a variety of phenylpropanoids, was investigated against three fungi, Candida albicans, Saccharomyces cerevisiae, and Pityrosporum ovale. Nagilactone E [2], the most

Nagilactone E suppresses TGF-β1-induced epithelial-mesenchymal transition, migration and invasion in non-small cell lung cancer cells.

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Non-small cell lung cancer (NSCLC) is one of the leading causes of cancer-related death around the world. Epithelial-mesenchymal transition (EMT) has been documented to increase motility and invasiveness of cancer cells, which promotes cancer

Downregulation of Cyclin B1 mediates nagilactone E-induced G2 phase cell cycle arrest in non-small cell lung cancer cells.

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Non-small cell lung cancer (NSCLC) is one of the most common forms and leading causes of cancer-related mortality worldwide, and discovery of new effective drugs still remains imperative to improve the survival rate. Nagilactone E (NLE) is a natural product isolated from Podocarpus nagi seeds, which

Antiproliferative Constituents of the Roots of Ethiopian Podocarpus falcatus and Structure Revision of 2α-Hydroxynagilactone F and Nagilactone I.

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Bioassay-guided fractionation using the human colorectal adenocarcinoma (HT-29) cell line of the methanol extract of dried roots of Podocarpus falcatus led to the isolation of two new type C nagilactones, 16-hydroxynagilactone F (1) and 2β,16-dihydroxynagilactone F (2), and the new totarane-type

Nagilactone E increases PD-L1 expression through activation of c-Jun in lung cancer cells

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Nagilactone E (NLE), a natural product with anticancer activities, is isolated from Podocarpus nagi. In this study, we reported that NLE increased programmed death ligand 1 (PD-L1) expressions at both protein and mRNA levels in human lung cancer cells, and enhanced its localization on the cell

Identification of nagilactone E as a protein synthesis inhibitor with anticancer activity.

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Norditerpenoids and dinorditerpenoids represent diterpenoids widely distributed in the genus Podocarpus with notable chemical structures and biological activities. We previously reported that nagilactone E (NLE), a dinorditerpenoid isolated from Podocarpus nagi, possessed anticancer effects against

Effect of nagilactone E on cell morphology and glucan biosynthesis in budding yeast Saccharomyces cerevisiae.

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Nagilactones are norditerpene dilactones isolated from the root bark of Podocarpus nagi. Although nagilactone E has been reported to show antifungal activities, its activity is weaker than that of antifungals on the market. Nagilactone E enhances the antifungal activity of phenylpropanoids such as

An antiproliferative norditerpene dilactone, Nagilactone C, from Podocarpus neriifolius.

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An ethanolic extract of Podocarpus neriifolius D. Don (Podocarpaceae) showed antiproliferative activity against two major tumor cell lines, viz. human HT-1080 fibrosarcoma and murine color 26-L5 carcinoma. Bioassay guided fractionation showed the highest antiproliferative activity in

Anticancer Activities and Mechanism of Action of Nagilactones, a Group of Terpenoid Lactones Isolated from Podocarpus Species

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Nagilactones are tetracyclic natural products isolated from various Podocarpus species. These lactone-based compounds display a range of pharmacological effects, including antifungal, anti-atherosclerosis, anti-inflammatory and anticancer activities reviewed here. The most active derivatives, such

Insect-control chemicals from plants. Nagilactone C, a toxic substance from the leaves of Podocarpus nivalis and P. hallii.

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Diterpenes, ionol-derived, and flavone glycosides from Podocarpus elongatus.

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Eight compounds, nagilactone C 7-O-α-L-arabinopyranosyl-(1→4)-β-D-xylopyranoside, nagilactone C 7-O-β-D-glucopyranosyl-(1→4)-β-D-xylopyranoside, nagilactone C 7-O-β-D-xylopyranoside, nagilactone A 7-O-α-L-arabinopyranosyl-(1→4)-β-D-xylopyranoside, 2β,15S,16,17,19-pentahydroxy-isopimar-8(14)-ene

Three diterpene dilactone glycosides from Podocarpus nagi.

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Three water-soluble constituents, nagilactosides C-E, were isolated from Podocarpus nagi. Their structures were determined by chemical and spectroscopic methods, respectively. Nagilactoside C was identified as 1-deoxy-nagilactone A-2 alpha-O-beta-D-glucopyranosyl-(1-->3)-beta-D-glucopyranoside,

Inhibition of lipid peroxidation by diterpenoid from Podocarpus nagi.

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A diterpenoid, totarol (1), from Podocarpus nagi was evaluated as an antioxidant. This diterpenoid inhibited autoxidation of linoleic acid. Mitochondrial and microsomal lipid peroxidation induced by Fe(III)-ADP/NADH or Fe(III)-ADP/NADPH were also inhibited. Nagilactone E (2), a norditerpene lactone

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