neohesperidin/hypersensitivity

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Neohesperidin suppresses IgE-mediated anaphylactic reactions and mast cell activation via Lyn-PLC-Ca2+ pathway.

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Mast cells play an essential role in IgE-FcεR1-mediated allergic diseases. Citrus aurantium is a prolific source of flavonoids with various biological activities, including anti-inflammatory, antioxidant, and anti-tumor efficacies. Neohesperidin is a novel flavonoid isolated from the leaves of C.

Comparative evaluation of 12 immature citrus fruit extracts for the inhibition of cytochrome P450 isoform activities.

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In a previous study we found that 50% ethanol extracts of immature fruits of Citrus unshiu (satsuma mandarin) have anti-allergic effects against the Type I, II and IV allergic reactions. However, many adverse interactions between citrus fruit, especially grapefruit juice, and drugs have been

[History and therapeutic evaluation of Citrus hassaku HORT. Tanaka].

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The original plant of Citrus hassaku HORT. Tanaka was found at Jyoudo-Temple in Inno-shima, Hiroshima Prefecture, Japan by Ekei Shounin in the Edo Era. Today, the fresh raw fruits of C. hassaku are cultivated as a seasonal food, and the most famous producing district of the C. hassaku fruit is

[Historical and pharmalogical study of Citrus hassaku.].

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The original plant of Citrus hassaku Hort. Tanaka was found at the Jyoudo Temple in Inno-shima, Hiroshima Prefecture, Japan by Ekei Shounin in the Edo Era. Citrus hassaku has been called "jagada" when it was first discovered. Since this fruit was seasoned for eating around "hassaku" (August 1st of

Antiallergic activity of unripe Citrus hassaku fruits extract and its flavanone glycosides on chemical substance-induced dermatitis in mice.

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Oral administration of a 50% ethanolic extract (CH-ext) obtained from unripe Citrus hassaku fruits collected in July exhibited a potent dose-dependent inhibition of IgE (immunoglobulin E)-mediated triphasic cutaneous reaction at 1 h [immediate phase response (IPR)], 24 h [late phase response (LPR)]

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