neuritis/phosphatase

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The role of macrophages in demyelination in experimental allergic neuritis.

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The role of macrophages and serum factors in demyelination in experimental allergic neuritis (EAN) was examined by a simple in vitro method. Cultivated rabbit peritoneal macrophages, preincubated with serum obtained from rabbit EAN produced by sensitization with bovine spinal nerve roots, could

Early changes in the Schwann cells in experimental allergic neuritis.

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Experimental allergic neuritis (EAN) was induced in guinea-pigs by intradermal injection of rabbit peripheral nerve emulsified in Freund's adjuvant. Both sciatic nerves were obtained between 12--24 hr after clinical symptoms were evident. Several fascicles from each nerve were isolated for

Optimal management of amiodarone therapy: efficacy and side effects.

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OBJECTIVE To review management and dosing guidelines for amiodarone therapy, and discuss the drug's adverse event profile. METHODS Review of relevant studies and reports. RESULTS Amiodarone is a highly effective antiarrhythmic drug, but is associated with adverse effects involving several organs.

Brain tumours in childhood in Bombay: I: Histopathology showing changing patterns; II: Tissue culture with light and electronmicroscopy, stressing ingestion & degradation of bacteria by glial cells in vitro.

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The pathological pattern of 86 brain 'tumours' in childhood during the years 1981-85 (out of a total of 586 for all ages), showed a higher proportion of neoplasms and a much lower of tuberculomas compared to the preceding three decades. A large number of histologically unusual cases was revealed.

Pathological effects of glyoxalase I inhibition in SH-SY5Y neuroblastoma cells.

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In Alzheimer's disease (AD), in aging, and under conditions of oxidative stress, the levels of reactive carbonyl compounds continuously increase. Accumulating carbonyl levels might be caused by an impaired enzymatic detoxification system. The major dicarbonyl detoxifying system is the glyoxalase

Lipocortin-1 (annexin-1) suppresses activation of autoimmune T cell lines in the Lewis rat.

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Increased levels of lipocortins occur in the nervous system in multiple sclerosis, in experimental autoimmune encephalomyelitis and experimental neuritis at the height of disease and decrease thereafter, suggesting their potential involvement in recovery from disease. We therefore investigated

Induction of lysosomal glycosidases by dibutyryl cAMP in neuroblastoma cells.

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We have studied the regulation of lysosomal glycosidases during morphological differentiation of NB2a neuroblastoma cells. Cells treated with dibutyryl cAMP induced axon-like neuritis and showed a 2-4 fold increase in the activity of 6 lysosomal glycosidases, reaching their highest level after 5

Histochemical abnormalities of skeletal muscle in patients with acute psychoses.

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In 29 acutely psychotic patients (mostly schizophrenic), histochemical abnormalities of a myopathic type were demonstrated in skeletal muscle biopsies from 13 and were generally correlated with elevation of the "muscle" type isoenzymes of creatine phosphokinase in the patients' serum. The incidence

[Myeloma and osteocondensation (apropos of 2 cases)].

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The authors report two cases of multiple myeloma which were typical both clinically and in the laboratory but XRay examination, on the other hand, showed appearances of osteocondensation. In the first case, XRay showed both lesions of osteolysis in the cranial vault and homogeneous condensation of

Possible link of genetic variants to autoimmunity in GAD-antibody-associated neurological disorders.

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In patients with GAD-antibody (ab) associated neurological disorders coexistence of other autoimmune disorders is observed.In this exploratory study we analysed variations in 33 candidate genes involved in autoimmunity or representing immunological

Characterization of the receptors for axon guidance factor netrin-4 and identification of the binding domains.

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Netrins are a family of secreted protein related to laminin and act as tropic cues directing axon growth and cell migration during neural development. Netrin-4 is a novel member of netrin family recently identified in the vertebrate with neuritis elongation promoting activity; however, the receptors

BRI2 and BRI3 are functionally distinct phosphoproteins.

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Three BRI protein family members have been identified. Among these are BRI3 and BRI2, the latter is associated with Familial Danish and Familial British dementias. 'In silico' sequence analysis identified putative PP1 binding sites in BRI2 and BRI3. This is singularly important, given that protein

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