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4 rezilta yo
Kindling of seizures with norharman, a beta-carboline ligand of benzodiazepine receptors.
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Quantitative autoradiography of [3H]norharman [( 3H]beta-carboline) binding sites in the rat brain.
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The anatomical distribution of [3H]norharman binding sites was determined by quantitative autoradiography in rat brain slices. They are enriched in hypothalamic, thalamic, accumbens and amygdaloid nuclei as well as in hippocampal, neocortical and olfactory-related structures. The distribution
Beta-carboline kindling of the benzodiazepine receptor.
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Beta-Carboline (norharman), an antagonist of the benzodiazepine receptor, given daily at a dose of 20 mg/kg (i.p.), produces kindled seizures. The mechanism of this epileptogenesis is unknown; however, other ligands of the benzodiazepine receptor, i.e. diazepam, R015-1788 and CL218-872 block the
Ro 15-1788 suppresses the development of kindling through the benzodiazepine receptor.
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beta-Carboline (norharman) has been shown to produce kindled seizures when given systemically for long periods of time. The expression of the kindled seizure activity can be blocked by ligands of the benzodiazepine receptor suggesting the receptor as a site of vulnerability in the kindling
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