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In necrosis of the liver of the dog produced by haemotoxic immune sera, the increased excretion of uric acid, purin bases and inorganic phosphorus pentoxide is the result of the hydrolysis of nuclear material occurring during the autolysis of the necrotic tissue.
The most marked chemical changes in a disintegrating spleen are noticed during the period when karyorrhexis and karyolysis are the characteristic features. When pyknosis alone is prominent almost all of the several constituents are in the coagulable or precipitable fraction, just as they are in the
Significant shifts were revealed in the content, disintegration, and synthesis of nucleic acids in the zone of the infarction and adjacent areas of the heart in experiments on 83 dogs. In the area of the necrosis, the total level and RNA transformation are reduced at the beginning but grow with the