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Herbal bioactivation: the good, the bad and the ugly.

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It has been well established that the formation of reactive metabolites of drugs is associated with drug toxicity. Similarly, there are accumulating data suggesting the role of the formation of reactive metabolites/intermediates through bioactivation in herbal toxicity and carcinogenicity. It has

Metabolic activation of herbal and dietary constituents and its clinical and toxicological implications: an update.

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In recent years, there has been a globally increasing application of herbal medicines and dietary supplements to treat various chronic diseases and to promote health. However, there are increasing clinical reports on the organ toxicities associated with consumption of herbal medicines. This review

Cow's urine concoction: its chemical composition, pharmacological actions and mode of lethality.

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A review of current information on the composition, pharmacological actions and mode of death from cow's urine concoction (CUC) toxicity is presented. The concoction is prepared from leaves of tobacco, garlic and basil; lemon juice, rock salt and bulbs of onion. The latter items are soaked in the

Herbal bioactivation, molecular targets and the toxicity relevance.

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There have been increasing reports on the adverse reactions associated with herbal consumption. For many of these adverse reactions, the underlying biochemical mechanisms are unknown, but bioactivation of herbal compounds to generate reactive intermediates have been implicated. This minireview

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Herbal & Natural Medicine

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