phosphatidyl ethanolamine/atrophy

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13 rezilta yo

Deterioration of membrane morphology, phospholipids, and cytoskeletal protein in rat erythrocytes exposed to tert-butyl hydroperoxide: protection by exogenous glutathione fails in selenium deficiency.

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Here we report scanning electron microscopy, phospholipid and fatty acid composition and cytoskeleton proteins of erythrocytes from Se-adequate and Se-deficient rats, showing protection by glutathione (GSH) against tert-butyl hydroperoxide (t-BuOOH)-induced hemolysis of erythrocytes from

Fluorescent pigments of the retinal pigment epithelium and age-related macular degeneration.

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The major hydrophobic fluorophore of the retinal pigment epithelium (RPE) is A2E, a pyridinium bis-retinoid derived from all-trans-retinal and phosphatidyl-ethanolamine. The accumulation of fluorophores such as A2E is implicated in the pathogenesis of age-related macular degeneration (AMD), a

The British Comparative Thromboplastin: the relationship between lipid class composition and procoagulant activity.

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Twenty-eight consecutive batches of the reference reagent British Comparative Thromboplastin (BCT) were produced in the National (UK) Reference Laboratory for Anticoagulant Reagents and Control (NRLARC) between 1969 and 1977. The relationship between procoagulant activity and lipid class composition

Functional analysis of genetic mutations in nucleotide binding domain 2 of the human retina specific ABC transporter.

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The rod outer segment (ROS) ABC transporter (ABCR) plays an important role in the outer segment of retinal rod cells, where it functions as a transporter of all-trans retinal, most probably as the complex lipid, retinylidene-phosphatidyl-ethanolamine. We report here a quantitative analysis of the

Microchromatographic analysis of lipids, protein, and occurrence of lipid peroxidation in various brain areas of vanadium exposed rats: a possible mechanism of vanadium neurotoxicity.

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Administration of sodium metavanadate (3 mg/kg) to adult female Sprague Dawley rats for 5 consecutive days by intreaeritoneal route resulted in major alterations in lipid profiles and protein concentration in all the brain regions. Sodium metavanadate exposure displayed phospholipids, cholesterol

Microchromatographic analysis of lipids, protein, and occurrence of lipid peroxidation in various brain areas of vanadium exposed rats: a possible mechanism of vanadium neurotoxicity.

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Administration of sodium metavanadate (3 mg/kg) to adult female Sprague Dawley rats for 5 consecutive days by intraperitoneal route resulted in major alterations in lipid profiles and protein concentration in all the brain regions. Sodium metavanadate exposure displayed significant decrease in the

[Pathohistologic and biochemical changes in the brain in atherosclerosis and atherosclerotic dementia].

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Results of clinico-morphological and biochemical examinations of 66 autopsy cases are presented. At lifetime the deceased were suffering from atherosclerosis: 16 of them showed no psychotic disturbances; 14 had a pseudoparalytic, 20 a lacunar, and 14 a senile-like form of dementia. With the use of

Peripheral nerve phospholipid composition: development in normal nerve and age-dependent changes in Wallerian degenerated nerve.

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The phospholipid composition of normal peripheral nerve as a function of developmental age as well as that of Wallerian-degenerated nerve as a function of age at nerve transection and duration of Wallerian degeneration have been quantitated in rabbit sciatic nerve. During development, increases in

[Changes in phospholipids in the gray and white matter of the rat brain during postmortem autolysis dynamics].

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Content of total phospholipids and their individual fractions, studied in rat brain grey and white substances during postmortal autolysis, was distinctly and dissimilarly altered in these tissues and the rate of alterations depended on time of incubation. Relative content of phosphatidyl serines +

High density lipoprotein mediated lipid efflux from retinal pigment epithelial cells in culture.

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OBJECTIVE [corrected] The transport of radiolabelled photoreceptor outer segments (POS) lipids was investigated by cultured retinal pigment epithelial cells (RPE). Phagocytosis of POS by the RPE is essential to maintain the health and function of the photoreceptors in vivo. POS are phagocytised at

Rat brain fatty acid composition: effect of dietary fat and age.

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The polyunsaturated fatty acid composition of human brain changes, as well as progressively decreases, with age. To determine if whole brain rat lipid shows similar changes with age, rats born to mothers fed semi-synthetic diets were raised on the same diet as their mothers for varying periods prior

Lipids of human retina, retinal pigment epithelium, and Bruch's membrane/choroid: comparison of macular and peripheral regions.

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OBJECTIVE To understand the difference between macular and peripheral regions, tissue samples of human retina, retinal pigment epithelium, and Bruch's membrane/choroid were dissected and analyzed for lipid composition. METHODS To facilitate dissections and enhance the recovery of tissues, eyecups

Lack of fundus autofluorescence to 488 nanometers from childhood on in patients with early-onset severe retinal dystrophy associated with mutations in RPE65.

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OBJECTIVE Fundus autofluorescence is due to accumulation of lipofuscin in the retinal pigment epithelium (RPE) resulting from incomplete digestion of N-retinylidene-phosphatidyl-ethanolamine from shed photoreceptor outer segment discs. Alteration in autofluorescence reflects changes in lipofuscin

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