podophyllotoxin/hemorrhage

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Long-term follow-up of endoscopic therapy of anal canal condylomata acuminata with podophyllotoxin.

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BACKGROUND Condylomata acuminata of the anal canal, a common sexually transmitted disease, are difficult-to-treat lesions with a high recurrence rate after initial successful treatment. OBJECTIVE Our aim was to evaluate by anoscopy the efficacy of podophyllotoxin 0.5% solution topically applied for

Camptothecin and podophyllotoxin derivatives: inhibitors of topoisomerase I and II - mechanisms of action, pharmacokinetics and toxicity profile.

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Camptothecins represent an established class of effective agents that selectively target topoisomerase I by trapping the catalytic intermediate of the topoisomerase I-DNA reaction, the cleavage complex. The water-soluble salt camptothecin-sodium - introduced in early trials in the 1960s - was highly

Modern management of genital warts in women.

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Genital warts are common and are a sexually transmitted disease affecting all socioeconomic groups and life-styles. They are caused by the human papillomavirus (HPV) and are highly contagious. Genital warts are often symptomless, but occasionally cause itching, bleeding after intercourse burning and

Symptomatic HPV-related neovaginal lesions in transgender women: case series and review of literature.

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OBJECTIVE Worldwide, transgender women are an at-risk population for contracting sexually transmitted infections. Little information exists on symptoms and characteristics of neovaginal human papillomavirus (HPV) infections and associated diseases. We describe a case series of transgender women with

Inhibition of Angiofibromas in a Tuberous Sclerosis Patient Using Topical Timolol 0.5% Gel.

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Angiofibromas are the most recognized cutaneous manifestations of tuberous sclerosis complex. Angiofibromas can be associated with disfigurement, bleeding, pruritus, and erythema and may lead to significant psychosocial consequences for affected patients. Histopathologically, angiofibromas consist

Myelodysplasia and the leukemias.

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The armistice after World War II marked the beginning of an era that was to last to the end of the present century. It was an era in which many changes in medicine and nursing combined to alter the entire philosophy of managing malignant disease. More specifically, the fluid-phase tumors, which

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