polygonum ganderbalense/Tonik

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Emodin inhibits tonic tension through suppressing PKCδ-mediated inhibition of myosin phosphatase in rat isolated thoracic aorta.

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OBJECTIVE Dysregulated tonic tension and calcium sensitization in blood vessels has frequently been observed in many cardiovascular diseases. Despite a huge therapeutic potential, little is known about natural products targeting tonic tension and calcium sensitization. METHODS We screened natural

Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb, Polygonum multiflorum.

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The main constituents of a typical medicinal herb, Polygonum multiflorum (Heshouwu in Chinese), that induces idiosyncratic liver injury remain unclear. Our previous work has shown that cotreatment with a nontoxic dose of lipopolysaccharide (LPS) and therapeutic dose of Heshouwu can induce liver

Erratum to: Screening for main components associated with the idiosyncratic hepatotoxicity of a tonic herb, Polygonum multiflorum

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The original version of this article unfortunately contained some mistakes.The panel of "LPS-/drug-" in Fig. 3B (Page 259), the panels of "LPS-/EtoAc+" and "LPS-/Residue+" in Supplementary Fig. 3 (Page 7 in the online supplementary materials) should be corrected. The authors apologize for this error

Biological Effects of Tetrahydroxystilbene Glucoside: An Active Component of a Rhizome Extracted from Polygonum multiflorum.

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Polygonum multiflorum Thunb. (PM), a traditional Chinese medicinal herb, has been widely used in the Orient as a tonic and antiaging agent. 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside (TSG, C₂₀H₂₂O₉, FW = 406.38928) is one of the active

Reduction of atherosclerosis in cholesterol-fed rabbits and decrease of expressions of intracellular adhesion molecule-1 and vascular endothelial growth factor in foam cells by a water-soluble fraction of Polygonum multiflorum.

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Polygonum multiflorum stilbeneglycoside (PMS) is a water-soluble fraction of Polygonum multiflorum Thunb., one of the most famous tonic traditional Chinese medicines, that has protective effects on the cardiovascular system. The purpose of the present study is to elucidate the effects of PMS on

[Bencao literature investigation of Polygonum multiflorum (Heshouwu)].

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Heshouwu, derived from the root of Polygonum multiflorum (=Fallopia multiflora), is widely used in the Chinese medicine market as a traditional tonic. The emergence of heshouwu material with a human shape reflects a pursuit of its supplementing effects. However, reports of Heshouwu toxicity have

Nuclear Factor Kappa B Activation and Peroxisome Proliferator-activated Receptor Transactivational Effects of Chemical Components of the Roots of Polygonum multiflorum.

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BACKGROUND Polygonum multiflorum is well-known as "Heshouwu" in traditional Chinese herbal medicine. In Northeast Asia, it is often used as a tonic to prevent premature aging of the kidney and liver, tendons, and bones and strengthening of the lower back and knees. OBJECTIVE To research the

Attributes of Polygonum multiflorum to transfigure red biotechnology.

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A vast array of plant-based compounds has enriched red biotechnology to serve the human health and food. A peculiar medicinal plant which was an element of traditional Chinese medicine for centuries as a liver and kidney tonic, for life longevity and hair blackening, is Polygonum multiflorum Thunb.

Components synergy between stilbenes and emodin derivatives contributes to hepatotoxicity induced by Polygonum multiflorum.

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Polygonum multiflorum Thunb. (PM) is a famous traditional Chinese medicine with liver tonic effect, but arousing great concerns for hepatotoxicity issue. In this study, we elucidated the contribution of the two major compounds, emodin-8-O-β-D-glucoside (EG) and

Screening for biomarkers of liver injury induced by Polygonum multiflorum: a targeted metabolomic study.

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Heshouwu (HSW), the dry roots of Polygonum multiflorum, a classical traditional Chinese medicine is used as a tonic for a wide range of conditions, particularly those associated with aging. However, it tends to be taken overdose or long term in these years, which has resulted in liver damage

[Textual research on illustration of Heshouwu in historical Bencao literature and its system of assessing quality by distinguishing features of traditional Chinese medicinal materials]

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As a medicine, Heshouwu was first appeared in Kaibao Bencao in Song Dynasty, which was a traditional tonic medicine. In recent years, the hepatotoxicity of Heshouwu has attracted great attention of domestic and foreign scholars. This paper has carried out textual research on illustration, quality

[Analysis of adverse reactions risk signal of Xinyuan Capsules based on national ADR monitoring spontaneous reporting system]

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In recent years, the safety problems and events of traditional Chinese medicine represented by liver injury have occurred frequently. In particular, Polygonum multiflorum has been widely used and considered as a "non-toxic" tonic traditional Chinese medicine for thousands of years.

[Research progress of liver injury induced by Polygoni Mulitiflori Radix]

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Polygoni Mulitiflori Radix, or dried root tuber of Polygonum multiflorum(PM), is a traditional Chinese tonic medicine, with the effect in nourishing liver and kidney, and benefiting blood essence and hair. It is widely used in clinical and healthcare products. In recent years, more and more reports

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