prolactinoma/phosphatase

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Relation of RANKL and OPG Levels with Bone Resorption in Patients with Acromegaly and Prolactinoma.

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The objective of this study was to investigate the effect of hyperprolactinemia and high levels of insulin-like growth factor-I (IGF-I) on bone resorption and their relation with receptor activator of nuclear factor-κB ligand (RANKL) and osteoprotegerin (OPG) in patients with prolactinoma and

Prolactinomas in adolescents: persistent bone loss after 2 years of prolactin normalization.

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OBJECTIVE To evaluate the effect of hyperprolactinaemia and its treatment with dopamine-agonists on bone mass and turnover in adolescent patients compared to adults. METHODS Forty patients with hyperprolactinaemia (20 with disease onset during adolescence and 20 during adulthood) and 40 healthy

Unusual case of Cowden-like syndrome, neck paraganglioma, and pituitary adenoma.

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BACKGROUND Pituitary tumors, paragangliomas, and Cowden syndrome do not usually occur together. METHODS The synchronous presentation of papillary thyroid carcinoma and neck paraganglioma was revealed in a 43-year-old woman who had been diagnosed with a microprolactinoma one decade before and now

Detection of chromogranins A and B in endocrine tissues with radioactive and biotinylated oligonucleotide probes.

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We analyzed the distribution of chromogranins A and B in normal and neoplastic endocrine tissues with secretory granules using 35S-labeled and biotin-labeled oligonucleotide probes by in situ hybridization (ISH). Both radioactive and nonradioactive probes detected messenger RNAs (mRNAs) in frozen

Various risks of osteoporosis in patients with pituitary adenomas.

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Some pituitary adenomas seem to be related to bone loss. It is unknown what kinds of pituitary adenomas affect bone mass. We attempted to determine what kinds of pituitary adenomas caused osteoporosis, and whether hormonal disturbance in pituitary adenoma patients affected bone mass. This study

Oestrogen and testosterone effects on hormone secretion and cell morphology of human pituitary tumours.

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Estradurin (a polymer of 17-beta-oestradiol) has an inhibitory effect on the synthesis/secretion of PRL. This effect is assumed to be caused by the strong inhibitory effect of the drug on phosphatases. With increasing time of low doses of Estradurin (0.001 micrograms/ml) in vitro, the inhibitory

Neural cell adhesion molecule expression in human pituitary adenomas.

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Neural cell adhesion molecule (NCAM) is a cell surface glycoprotein whose expression may be important in metastatic or local growth of neoplasms. Expression of NCAM in human pituitary adenomas was assessed on snap-frozen and Bouin's and/or formalin-fixed, paraffin-embedded archival tissue using a

Osteoporotic vertebral fractures during pregnancy: be aware of a potential underlying genetic cause.

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BACKGROUND Although the baby growing in its mother's womb needs calcium for skeletal development, osteoporosis and fractures very rarely occur during pregnancy. METHODS A 27-year-old woman in the seventh month of her first pregnancy contracted midthoracic back pain after lifting an object. The pain

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