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pulsatilla patens/scopolamine
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SK-PC-B70M from Pulsatilla koreana improves scopolamine-induced impairments of memory consolidation and spatial working memory.
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Previous studies have shown that hederacolchiside-E from Pulsatilla koreana has neuroprotective effects and cognition-enhancing effects. Subsequently, in the current study, we demonstrate that oral administrations of oleanolic-glycoside saponins enriched fraction from P. koreana, designated as
SK-PC-B70M alleviates neurologic symptoms in G93A-SOD1 amyotrophic lateral sclerosis mice.
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SK-PC-B70M, an oleanolic-glycoside saponins fraction extracted from the root of Pulsatilla koreana, carries active ingredient(s) that protects the cytotoxicity induced by Aβ(1-42) in SK-N-SH cells. It was recently demonstrated that SK-PC-B70M improved scopolamine-induced deficits of memory
SK-PC-B70M confers anti-oxidant activity and reduces Abeta levels in the brain of Tg2576 mice.
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SK-PC-B70M is an oleanolic-glycoside saponin-enriched fraction derived from the root of Pulsatilla koreana. Recently, it was reported that hederacolchiside-E is an active ingredient of SK-PC-B70M that confers a neuroprotective effect against the cytotoxicity induced by Abeta(1-42) in SK-N-SH
Cognition-enhancing and neuroprotective effects of hederacolchiside-E from Pulsatilla koreana.
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The root extract of Pulsatilla koreana (Ranunculaceae) has been found to have prominent abilities to reverse scopolamine-induced cognitive impairment in rats, and to increase the viability of human neuroblastoma SK-N-SH cells incubated with amyloid-beta peptide (1 - 42) [A beta (1 - 42)]. In vivo
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