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BACKGROUND
Rheum palmatum L. and Coptis chinensis Franch., are two representative cold-natured traditional Chinese medicine with heat-clearing effect, and were widely used to treat fever associated diseases in China for a long history. To elucidate the mechanism of the antipyretic effect of Rheum
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In traditional Chinese medicine (TCM), there are three Cheng-Chi-Tang decoctions (CCTDs) including: Ta-Cheng-Chi-Tang (TCCT), Xiao-Chen-Chi-Tang (XCCT) and Tiao-Wei-Chen-Chi-Tang (TWCCT), which are the frequently used purgative remedies to treat "internal heat"-induced symptoms like a bloated and
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