scoparone/kansè

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Scoparone exerts anti-tumor activity against DU145 prostate cancer cells via inhibition of STAT3 activity.

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Scoparone, a natural compound isolated from Artemisia capillaris, has been used in Chinese herbal medicine to treat neonatal jaundice. Signal transducer and activator of transcription 3 (STAT3) contributes to the growth and survival of many human tumors. This study was undertaken to investigate the

Scoparone attenuates RANKL-induced osteoclastic differentiation through controlling reactive oxygen species production and scavenging.

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Scoparone, one of the bioactive components of Artemisia capillaris Thunb, has various biological properties including immunosuppressive, hepatoprotective, anti-allergic, anti-inflammatory, and antioxidant effects. This study aims at evaluating the anti-osteoporotic effect of scoparone and its

Anti-allergic effects of scoparone on mast cell-mediated allergy model.

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Scoparone is known to have a wide range of pharmacological properties in vitro. However, the roles of scoparone in immediate-type allergic reactions have not yet been investigated. In this study, we demonstrated that scoparone attenuated IgE-mediated allergic response in mast cells. Oral

Scoparone attenuates high glucose-induced extracellular matrix accumulation in rat mesangial cells.

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Scoparone, a major constituent of Artemisia capillaries, has a variety of biological properties including anticoagulant, hepatoprotective, anti-tumor, anti-fibrosis, anti-inflammatory, antioxidant, and antidiabetic activities. However, the renoprotective effect of scoparone under diabetic conditions

Inhibitory effects of scoparone from chestnut inner shell on platelet-derived growth factor-BB-induced vascular smooth muscle cell migration and vascular neointima hyperplasia.

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Compounds of the inner shell of chestnut (Castanea crenata) have diverse biological activities, including anti-cancer and anti-oxidant activities. Here we explored the effects of an extract of chestnut inner shells and of its bioactive component scoparone on vascular smooth muscle cell

7-substituted coumarins inhibit proliferation and migration of laryngeal cancer cells in vitro.

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BACKGROUND Coumarins are a large group of naturally-occurring compounds with a wide range of biological properties, including anticancer activity. 7-Substituted coumarins (umbelliferone, scoparone, and herniarin) were analyzed for their potential anticancer activity against laryngeal cancer cells

Anti-Osteoclastic Activity of Artemisia capillaris Thunb. Extract Depends upon Attenuation of Osteoclast Differentiation and Bone Resorption-Associated Acidification Due to Chlorogenic Acid, Hyperoside, and Scoparone.

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The present study attempts to elucidate the anti-osteoporotic activity of Artemisia capillaris Thunb. in the form of anti-osteoclastic effect and responsible bioactive compounds. The contents of chlorogenic acid, caffeic acid, hyperoside, isoquercitrin, isochlorogenic acid A, and scoparone in

Scoparone from Artemisia capillaris inhibits the release of inflammatory mediators in RAW 264.7 cells upon stimulation cells by interferon-gamma Plus LPS.

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Scoparone is a major component of the shoot of Artemisia capillaris (Compositae), which has been used for the treatment of hepatitis and biliary tract infection in oriental countries. In the present study we observed that, scorparone exhibited no cytotoxic effect in unstimulated macrophages, but

Scoparone attenuates angiotensin II-induced extracellular matrix remodeling in cardiac fibroblasts.

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Scoparone is a biologically active constituent isolated from Artemisia capillaris and possesses a variety of pharmacological activities, such as anti-inflammatory, anti-tumor, anti-allergic and anti-cardiovascular activities. However, there are no studies focusing on the effects of scoparone against

Therapeutic effects of scoparone on pilocarpine (Pilo)-induced seizures in mice.

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Epilepsy is a common and devastating neurological disorder. Inflammatory processes and apoptosis in brain tissue have been reported in human epilepsy. Scoparone (6,7-dimethoxycoumarin) is an important chemical substance, which has multiple beneficial activities, including antitumor,

Cytotoxic Properties of the Stem Bark of Citrus reticulata Blanco (Rutaceae).

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The bioassay-guided fractionation of the n-hexane extract of Citrus reticulata Blanco (Rutaceae) stem bark yielded scoparone (1), xanthyletin (2), lupeol (3), β-amyrin (4), stigmasterol (5), β-sitosterol (6) and palmitic acid. The structures of these compounds were determined by comprehensive

GC-MS explores the health care components in the extract of Pterocarpus pedatus Pierre.

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Pterocarpus a high-end, expensive furniture materials collectively. Pterocarpus and Pterocarpus products have a certain human health function. Therefore, this paper to Pterocarpus pedatus Pierre as an example, to study its extract on human health beneficial health care ingredients. FT-IR analysis

A new sesquiterpene and other terpenoid constituents of Chisocheton penduliflorus.

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A new aromadendrane sesquiterpene, allo-aromadendrane-10alpha, 14-diol (3), was isolated from Chisocheton penduliflorus (Meliaceae), along with two known sesquiterpenes: allo-aromadendrane-10beta, 14-diol (2) and allo-aromadendrane-10beta, 13, 14-triol (7). Six dammarane triterpenoids, including

A new naphthol from the twigs and leaves of Pterospermum yunnanense.

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A new naphthol, 7-hydroxy-6-methyl-1-naphthoic acid methyl ester (1), together with eight known compounds, 6-hydroxy-7-(hydroxymethyl)-1-isopropyl-4-methyl-naphthalene (2), α-hydroxyacetosyringone (3), hexadecyl ferulate (4), scoparone (5), (+)-syringaresinol (6), stigmast-1,5-dien-3β-ol (7),

Natural products from Cuscuta reflexa Roxb. with antiproliferation activities in HCT116 colorectal cell lines.

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Parasitic Cuscuta reflexa Roxb. possesses many medicinal properties and is a rich source of a variety of biologically relevant natural products. Natural products are the prime source of leads, drugs, and drug templates, and many of the anticancer and antiviral drugs are either based on natural

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