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stepholidine/catalepsy
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Atypical neuroleptic properties ofl-stepholidine : Electrophysiological and behavioral studies.
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Intravenous administration ofl-stepholidine (SPD), a dopamine (DA) receptor antagonist, increased the firing rate of DA neurons located in the ventral tegmental area (VTA) and substantia nigra pars compacta (SNC) in both anaesthetized and paralyzed rats. However, with the increase of dose, SPD
The antipsychotic potential of l-stepholidine--a naturally occurring dopamine receptor D1 agonist and D2 antagonist.
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BACKGROUND
l-Stepholidine, a dopamine D(2) antagonist with D(1) agonist activity, should in theory control psychosis and treat cognitive symptoms by enhancing cortical dopamine transmission. Though several articles describe its impact on the dopamine system, it has not been systematically evaluated
[Effect of (+/-)12-chloroscoulerine on brain dopamine receptors].
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OBJECTIVE
To assess potencies of tetrahydroprotoberberines (THPB) and hydrobenzyltetrahydroisoquinolines (HBTI) on DA receptors.
METHODS
The receptor binding assay with calf striatum to D1 and D2 receptors, and the animal behavior tests were used.
RESULTS
(+/-) 12-Chloroscoulerine (CSL) was the most
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