15 rezilta yo
Piglets were provided supplemental energy as oral doses of corn oil to find whether such treatment might improve survival or weight gains. A total of 1,840 piglets from 182 litters was used. Piglets were allotted to dosed and control treatments within litter on the basis of body weight. Dosed
Several epidemiological reports demonstrated that vitamin D deficiency elevated risk of preterm delivery. We investigate the effects of oral cholecalciferol (VD3) supplementation on lipopolysaccharide (LPS)-induced preterm delivery. Pregnant mice were randomly assigned to either oral VD3 (25 μg/kg)
Adult male Sprague Dawley rats were gavaged with 2,4-dinitrotoluene (2,4-DNT) dissolved in corn oil at 0, 60, 180, or 240 mg/kg/day for five days. A single oral dose (0.5 mg/kg) of triethylenemelamine was used as a positive control. Induction of dominant lethal events was scored on the basis of
1-Bromopropane (1-BP) is widely used in spray adhesives, precision cleaner, and degreaser. This study was conducted to investigate the potential of 1-BP to induce dominant lethality in mice. 1-BP was orally administered to males at doses of 300 and 600 mg/kg for 10 days before mating.
Bumped kinase inhibitors (BKIs) are effective against a variety of apicomplexan parasites. Fifteen BKIs with promising in vitro efficacy against Neospora caninum tachyzoites, low cytotoxicity in mammalian cells, and no toxic effects in non-pregnant BALB/c mice, were assessed in pregnant mice. Drugs
Methyl dihydrojasmonate (MDJ) is a widely used fragrance ingredient. MDJ was evaluated for developmental toxicity in presumed pregnant Sprague-Dawley rats (25/group) at oral dosages of 0, 40, 80 or 120 mg/kg/day in corn oil administered on gestational days 7-20. Dams were observed for viability,
A study was carried out to determine whether corn oil-based diets devoid of arachidonic acid, 20:4(n-6), are capable of supporting feline reproduction. One group of four adult female felines were acclimated to a 10 weight% (wt%) fat diet consisting of 1 wt% corn oil and 9 wt% hydrogenated coconut
BACKGROUND
Prenatal rat embryo exposure to retinoids induces severe malformations in various organs; the most active and teratogenic metabolite is all-trans-retinoic acid (atRA). The mechanisms of this embryopathy are only partly known. In the present study, the influence of glycine on the
Technical grade dinitrotoluene (DNT) was administered by gavage (po) to timed-pregnant Fischer 344 rats on Gestational Days (gd) 7 through 20. Mortality rates for the DNT (14, 35, 37.5, 75, 100, or 150 mg/kg/day) groups were 4.5, 7.7, 0.0, 0.0, 4.3, and 46.2% of treated females, respectively. No
Twelve pregnant gilts were assigned to three treatments (four gilts per treatment): (1) corn oil (control) injected subcutaneously four times daily from day 110 of gestation until onset of lactation; (2) 25 mg progesterone (P4) injected subcutaneously four times daily from day 110 of gestation
Alpha-iso-methylionone, a widely used fragrance ingredient, was evaluated for developmental toxicity in presumed pregnant Sprague-Dawley rats (25/group). Oral dosages of 0, 3, 10, or 30 mg/kg/day alpha-iso-methylionone in corn oil were administered by gavage on gestational days 7 to 17. The presence
OBJECTIVE
Brain tissue nodules are occasionally seen in the lungs of neural tube defect (NTD) cases. We looked for brain tissue fragments in amniotic fluid of rats with NTD as it is the basis for the aspiration hypothesis.
METHODS
Eighty-seven pregnant rats were randomly divided into experimental
Developmental disability, intrauterine growth retardation, renal anomalies, and dysmorphic features have been described in offspring of women who abuse toluene during pregnancy. A Sprague-Dawley rat model was developed to study this clinical syndrome. During d 6-19 of gestation, 11 treated dams
Isoeugenol, used as a perfumery and flavoring agent, was evaluated for developmental toxicity. Timed-pregnant CD((R)) outbred albino Sprague-Dawley rats received isoeugenol (250, 500, or 1000 mg/kg/day) or vehicle (5 ml/kg corn oil) by gavage on gestational days (gd) 6 through 19. Maternal food and
The effects of dietary fat or fructose supplementation during late gestation and lactation on sow milk production and composition and on progeny were examined. On d 88 of gestation, 24 sows were allotted by parity to three dietary treatments (eight sows/treatment). Treatments were 1) a 12.5% crude