Disclosed are compounds of Formula I useful in the treatment of cyclooxygenase mediated diseases such as pain, fever and inflammation of a variety of conditions including rheumatic fever, symptoms associated with influenza or other viral infections, common cold, low back and neck pain, dysmenorrhea, headache, toothache, sprains and strains, myositis, neuralgia, synovitis, arthritis, including rheumatoid arthritis degenerative joint diseases (osteoarthritis), gout and ankylosing spondylitis, bursitis, burns, injuries. ##STR1##

Merck Frosst Canada, Inc.

Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase

Isoxazolone compounds having the generic structure: ##STR1##are used to treat disease associated with unwanted cytokine activity, including rheumatoid arthritis, osteoarthritis, diabetes, HIV/AIDS, inflammatory bowel disease, Crohn's disease, ulcerative colitis, congestive heart, hypertension, chronic obstructive pulmonary disease, septic shock syndrome, tuberculosis, adult respiratory distress, asthma, atherosclerosis, muscle degeneration, periodontal disease, cachexia, Reiter's syndrome, gout, acute synovitis, anorexia and bulimia nervosa fever, malaise, myalgia and headaches.

The Procter &amp; Gamble Company

Isoxazolone compounds useful in treating diseases associated with unwanted cytokine activity

Disclosed is a pharmaceutical composition for preventing or treating TRPV1 activity-related or inflammation-related, diseases or conditions, containing a Maillard peptide separated from well-aged traditional soy sauce as an active ingredient. The Maillard peptide in the present invention functions both as a TRPV1 agonist and a TRPV1 antagonist, and further functions as a TRPV1 activity modulator. Therefore, the Maillard peptide can be used for preventing or treating TRPV1 activity-related diseases such as pain, neurological diseases, urgent defecation, inflammatory bowel disease, respiratory diseases, urinary incontinence, overactive bladder, neurogenic / allergic / inflammatory skin diseases, skin, eye or mucosal irritation, hyperacusis, tinnitus, vestibular hypersensitivity, heart disease, etc. The Maillard peptide can further inhibit COX-2 activity, and therefore can be effectively used for preventing or treating inflammation-related diseases or conditions such as rheumatic fever, influenza, cold, throat pain, headaches, toothaches, sprains, neuralgia, synovitis, rheumatoid arthritis, degenerative arthropathies, gout, ankylosing spondylitis, psoriasis, dermatitis, etc.

Rhyu; Mee-Ra

Song; Ah-Young

Kim; Eun-Young

Oh; Seog Bae

Lee; YoungJoo

Lim; Won Chung

Korea Food Research Institute

SNU R &amp; DB Foundation

Pharmaceutical composition for preventing / treating TRPV1 activity-related and inflammation-related diseases or conditions containing maillard peptide separated from well-aged traditional soy sauce as active ingredient

synovitis

lafyèv

fever

synovitis/lafyèv

Alkanesulfonamido-1-indanone derivatives as inhibitors of cyclooxygenase

Isoxazolone compounds useful in treating diseases associated with unwanted cytokine activity

Isoxazolone compounds useful in treating diseases associated with unwanted cytokine activity

Pharmaceutical composition for preventing / treating TRPV1 activity-related and inflammation-related diseases or conditions containing maillard peptide separated from well-aged traditional soy sauce as active ingredient

Baz done ki pi konplè remèd fèy medsin te apiye nan syans