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tabes dorsalis/phospholipase
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Phospholipase cbeta4 is specifically involved in climbing fiber synapse elimination in the developing cerebellum.
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Elimination of excess climbing fiber (CF)-Purkinje cell synapses during cerebellar development involves a signaling pathway that includes type 1 metabotropic glutamate receptor, Galphaq, and the gamma isoform of protein kinase C. To identify phospholipase C (PLC) isoforms involved in this process,
Roles of phospholipase Cbeta4 in synapse elimination and plasticity in developing and mature cerebellum.
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The beta isoforms of phospholipase C (PLCbetas) are thought to mediate signals from metabotropic glutamate receptor subtype 1 (mGluR1) that is crucial for the modulation of synaptic transmission and plasticity. Among four PLCbeta isoforms, PLCbeta4 is one of the two major isoforms expressed in
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