tanacetum macrophyllum/edema

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Isolation of two flavonoids from Tanacetum microphyllum as PMA-induced ear edema inhibitors.

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The CH2Cl2 extract of Tanacetum microphyllum exhibited antiinflammatory activity on PMA-mouse ear model. Two antiinflammatory flavonoids, 5,7-dihydroxy-3,6,4'-trimethoxyflavone (santin) (1) and 5,7-dihydroxy-3,4'-dimethoxyflavone (ermanin) (2), were isolated.

The analgesic, anti-inflammatory and calcium antagonist potential of Tanacetum artemisioides.

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Several species of the genus Tanacetum are traditionally used in a variety of health conditions including pain, inflammation, respiratory and gastrointestinal disorders. In the current investigation, we evaluated the plant extract of T. artemisioides and some of its pure compounds (flavonoids) for

Antinociceptive and anti-inflammatory effects of Tanacetum parthenium L. extract in mice and rats.

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Oral administration of the feverfew (Tanacetum parthenium) extract led to significant antinociceptive and anti-inflammatory effects against acetic acid-induced writhing in mice and carrageenan-induced paw edema in rats, respectively. These responses were dose-dependent (10, 20, 40 mg/kg, p.o.).

Anti-inflammatory activity of hydroxyachillin, a sesquiterpene lactone from Tanacetum microphyllum.

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The aerial parts of Tanacetum microphyllum D.C. (Compositae), used in folk medicine as an anti-inflammatory and anti-ulcer agent, were studied, the active principle hydroxyachillin (1) was isolated, and its pharmacological properties were analyzed. Hydroxyachillin showed marked anti-inflammatory

Suppression of inflammatory responses by handelin, a guaianolide dimer from Chrysanthemum boreale, via downregulation of NF-κB signaling and pro-inflammatory cytokine production.

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The anti-inflammatory activity of handelin (1), a guaianolide dimer from Chrysanthemum boreale flowers, was evaluated in vivo, and the effects on mediators nitric oxide (NO), prostaglandin E2 (PGE2), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β) and the nuclear factor-κB (NF-κB) and

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