teucrium polium/necrosis

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Hepatitis after germander (Teucrium chamaedrys) administration: another instance of herbal medicine hepatotoxicity.

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OBJECTIVE To show that germander (Teucrium chamaedrys), an herbal medicine used to facilitate weight loss, may be hepatotoxic and to delineate the nature of the injury. METHODS Retrospective study. METHODS Liver units of several centers in the French Network of Pharmacovigilance. METHODS Seven

Hepatotoxicity of germander (Teucrium chamaedrys L.) and one of its constituent neoclerodane diterpenes teucrin A in the mouse.

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The hepatotoxicity of the herbal plant germander and that of one of its major furanoneoclerodane diterpenes, teucrin A, were investigated in mice. Teucrin A was found to cause the same midzonal hepatic necrosis as observed with extracts of the powedered plant material. Evidence that bioactivation of

Acute hepatitis associated with herb (Teucrium capitatum L.) administration.

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Drug-induced hepatotoxicity due to medicinal plant administration has been infrequently reported. This case describes a 62-year-old Caucasian man with hypercholesterolaemia and hyperglycaemia, who started daily consumption of a tea containing the medicinal plant Teucrium capitatum L. Four months

Anti-allergic effects of Teucrium japonicum on mast cell-mediated allergy model.

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The mast cell-mediated immediate-type allergic reaction is involved in many allergic diseases such as asthma, allergic rhinitis, and sinusitis. Stimulation of mast cells starts the process of degranulation resulting in release of mediators such as histamine and an array of inflammatory cytokines. In

Protective effect of Teucrium polium on carbon tetrachloride induced genotoxicity and oxidative stress in rats.

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This study aimed to investigate the protective effects of Teucrium polium (TP) on carbon tetrachloride (CCl4) induced spleen, erythrocyte's oxidative stress, and genotoxicity in rats. TP was found to contain large amounts of polyphenols (150 mg GAE/G of dry plant) and flavonoids (60 mg QE/g of

Teucrium polium reversed the MCD diet-induced liver injury in rats.

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In the present study, we evaluated the ability of Teucrium polium ethyl acetate fraction, with high antioxidant activity, in the treatment of nonalcoholic steatohepatitis (NASH) in rats and its possible effect on factors involved in pathogenesis of the disease. To induce NASH, a methionine and

On the benefit of Teucrium in murine colitis through improvement of toxic inflammatory mediators.

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Regarding the role of free radicals in pathogenesis of inflammatory bowel disease (IBD), we were interested to investigate the effects of Teucrium persicum with approved antioxidant and anti-inflammatory properties in an experimental model of colitis. Immunologic colitis was induced by rectal

Anti-aging effects of some selected Iranian folk medicinal herbs-biochemical evidences.

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OBJECTIVE In the current study, the effects of selected folk medicinal herbs were evaluated in D-galactose-induced aging in male mice. METHODS Male BALB/c mice were randomly divided into 12 groups composing sham, control, and treated groups. Aging was induced by administration of D-galactose (500

Topical co-administration of Teucrium polium hydroethanolic extract and Aloe vera gel triggered wound healing by accelerating cell proliferation in diabetic mouse model.

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Diabetic wounds are major issues in patients with diabetes. Medicinal plants of Teucrium polium and Aloe vera have antioxidant and anti-inflammatory properties that may be profitable for diabetic patients. This study was conducted to evaluate the effect of co-administration of ointments prepared

Apigetrin from Scutellaria baicalensis Georgi Inhibits Neuroinflammation in BV-2 Microglia and Exerts Neuroprotective Effect in HT22 Hippocampal Cells.

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Apigetrin is a flavonoid isolated from various herbal medicines such as Scutellaria baicalensis Georgi, Matricaria chamomilla, Stachys tibetica Vatke, and Teucrium gnaphalodes. In the present study, we investigated the inhibitory effects of apigetrin on neuroinflammation using the BV-2 microglia

Hepatotoxicity of germander in mice.

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OBJECTIVE An epidemic of hepatitis due to germander teas or capsules recently occurred in France. The aim of the present study was to show the hepatotoxicity of germander and determine its mechanism in mice. METHODS A germander tea lyophilisate and a fraction that isolated and concentrated 10-fold

[Liver damage induced by the ingestion of a product of phytotherapy containing wild germander. Four cases].

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We report 4 cases of patients who developed hepatic injury during administration of herbal medicines for loosing weight with Wild Germander. Three developed jaundice and one had fatigue. Aminotransaminase activities were increased in all patients. Outcome was favorable after drug withdrawal in all

Antimutagenic effects of ethanolic extracts from selected Palestinian medicinal plants.

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OBJECTIVE Eryngium creticum, Nigella sativa, and Teucrium polium have been traditionally used for the treatment of inflammations, liver disorders, and arthritis. Various studies on these plants revealed anti-inflammatory, hepatoprotective and antimutagenic activities. Previous results of our

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