Salts of a bicyclic, N-acylated imidazo-3-amine or an imidazo-5-amine of the formula: ##STR00001## addition products thereof with acids, and methods for preparing the salts and addition products. Also disclosed are pharmaceutical compositions comprising the same and methods using the pharmaceutical compositions for the treatment or prophylaxis of pain, drug or alcohol abuse, diarrhoea, gastritis, ulcers, urinary incontinence, depression, narcolepsy, overweight, asthma, glaucoma, tinnitus, itching, hyperkinetic syndrome, epilepsy, or schizophrenia, for inducing anesthesia, and for anxiolysis.

Gruenenthal GmbH

Salts of bicyclic, N-acylated imidazo-3-amines and imidazo-5-amines

A method for agonizing or antagonizing the ORL1 (opioid receptor-like) receptor of the nociceptin/orphanin FQ ligand ORL1 receptor system using a morphinan compound of the general formula I or derivatives thereof. Also disclosed are methods for treating neuropathic pain and/or anxiolysis and/or depression and/or diuresis and/or urinary incontinence and/or hypotension and or hypertension and/or senile dementia and/or Alzheimer's disease and/or general cognitive disfunctions an/or tinnitus and/or impaired hearing and/or epilepsy and/or obesity and/or cachexia.

tinnitus/obesity

Salts of bicyclic, N-acylated imidazo-3-amines and imidazo-5-amines

Salts of bicyclic, N-acylated imidazo-3-amines and imidazo-5-amines

Use of morphine derivatives as medicaments for the treatment of neuropathic problems

Baz done ki pi konplè remèd fèy medsin te apiye nan syans