Use of nicotine lozenge plus behavioral counseling to help reduce tobacco use prior to quit date.

Use of behavioral counseling alone to help reduce tobacco use prior to quit date.

Tobacco Use Disorder

Nicotine Lozenge

Use of behavioral counseling to reduce tobacco use.

Behavioral Counseling

University of Minnesota

Nicotine Lozenge to Reduce Smokeless Tobacco Use

Treatment of Smokeless Tobacco Users

Dorothy Hatsukami

National Institute on Drug Abuse (NIDA)

Reduction in tobacco toxicants by switching to a lower nicotine tobacco product under a controlled use condition.

Reduction in tobacco toxicants by switching to a lower nicotine tobacco product under an uncontrolled use condition.

Reduction in smokeless tobacco use using behavioral techniques only.

Skoal for 50% reduction;Skoal bandits for 75% reduction.

Lower Nicotine Smokeless Tobacco Product

Behavioral counseling alone for reduction in tobacco use.

Using Smokeless Tobacco Products With Lower Nicotine Levels to Reduce Negative Effects of Smokeless Tobacco Use

Treatment of Smokeless Tobacco Users: Use of Nicotine Replacement Products to Reduce Smokeless Tobacco Use

Dorothy Hatuskami

Reduction of tobacco use by substituting tobacco free snuff.

Reduction of tobacco use by using behavioral techniques.

Tobacco free snuff

Effectiveness of Using Tobacco Free Snuff in Reducing Negative Effects of Smokeless Tobacco Use

Dorohty Hatsukami

Usual care for cessation with immediate quit date scheduled and two weeks of nicotine patch supplied.

Reduction in nicotine exposure for 6 weeks prior to quit date using medicinal nicotine lozenge or reduced nicotine smokeless tobacco.

Usual care consisted of setting an immediate quit date and receiving 2 weeks nicotine patch and behavioral counseling during the intervention period.

Usual Care Group

Subjects are instructed to reduce their tobacco use by 50% and then 75% over 6 weeks prior to quit date using nicotine lozenge or brand switching resulting in reduced nicotine exposure.

Reduction Group

Total

Sex: Female, Male

Region of Enrollment

No tobacco use 7 days prior to Week 12 verified by biomarkers (urine, cotinine and CO)

Percent Abstinent From Tobacco at Week 12 (7 Day Point Prevalence)

Continuous tobacco cessation from quit date through Week 12 verified by biomarkers (urine, cotinine and CO)

Usual Care consisted of setting an immediate quit date and receiving 2 weeks nicotine patch and behavioral counseling during the intervention period.

Reduction group subjects are instructed to reduce their tobacco use by 50% and then 75% over 6 weeks prior to quit date. Reduction is facilitated using nicotine lozenge or brand switching resulting in reduced nicotine exposure.

Percent Prolonged Abstinence From Tobacco at Week 12

Abstinence from tobacco 7 days prior to Week 26 (Assessed at 26 weeks for Usual Care and 20 weeks for Reduction Group post-quit date)

Percent Abstinent From Tobacco at Week 26 (7 Day Point Prevalence)

Continuous Abstinence from quit date through Week 26 (Assessed at Week 26 for Usual Care and Week 20 for Reduction Group, Reduction Group's quit date is 6 weeks later than Usual Care).

Percent Prolonged Abstinence From Tobacco at Week 26

Abstinence from tobacco 7 days prior to Week 26 (Assessed at Week 32 for Usual Care and Week 26 for Reduction Group. Reduction Group's quit date is 6 weeks later than Usual Care).

Percent Abstinent From Tobacco at Week 32 (7 Day Point Prevalence)

Continuous Abstinence from quit date through Week 32 (Assessed at Week 32 for Usual Care and Week 26 for Reduction Group, Reduction Group's quit date is 6 weeks later than Usual Care).

Percent Prolonged Abstinence From Tobacco at Week 32

Usual Care consisted of setting an immediate quit date and receiving 2 weeks of nicotine patch and behavioral counseling during the 6 week intervention period.

Subjects are instructed to reduce their tobacco use by 50% and then 75% over 6 weeks prior to quit date. Reduction is facilitated by using nicotine lozenge or ST brand switching resulting in reduced nicotine exposure.

Overall Study

Dorothy Hatsukami, Ph.D.

Subject selects preferred method for reduction.

Schiller KR, Luo X, Anderson AJ, Jensen JA, Allen SS, Hatsukami DK. Comparing an immediate cessation versus reduction approach to smokeless tobacco cessation. Nicotine Tob Res 2012.

tooth wear/nicotine

Nicotine Lozenge to Reduce Smokeless Tobacco Use

Using Smokeless Tobacco Products With Lower Nicotine Levels to Reduce Negative Effects of Smokeless Tobacco Use

Effectiveness of Using Tobacco Free Snuff in Reducing Negative Effects of Smokeless Tobacco Use

Comparison Across Treatment Conditions to Reduce Smokeless Tobacco Use

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