Chronic Periodontitis

Type 2 Diabetes

Periodontal intervention All patients were instructed in oral hygiene methods using a soft bristled toothbrush, a compact-tuft toothbrush, interdental brushes and dental floss utilizing the modified Bass technique. Full mouth debridement, which consisted of scaling and root planing, was done in a single visit for all subjects using an ultrasonic scaler and gracey curettes. Additionally, all patients were given a 0.12% Chlorhexidine mouthrinse (Hexipro®). They were instructed to rinse three times a day using 15ml each time for a period of 14 days commencing immediately after completion of full mouth debridement. Thereafter at each recall visit, all participants were re-motivated and professional prophylaxis was performed.

Nonsurgical periodontal therapy

All patients were instructed in oral hygiene methods using a soft bristled toothbrush, a compact-tuft toothbrush, interdental brushes and dental floss utilizing the modified Bass technique.

Oral hygiene instructions

Faculty of Dentistry, University of Malaya

The Periodontal Disease and Diabetes Mellitus Interrelationship Among Adult Malaysians

The Effect of Non-surgical Periodontal Therapy on Host Response and Microbiological Profile of Type 2 Diabetics With Periodontal Disease.

Plaque score levels were evaluated at baseline, 2- and 3-months intervals

Gingival bleeding index levels were evaluated at baseline, 2- and 3-months intervals

Probing pocket depths were evaluated at baseline, 2- and 3-months intervals

Probing attachment levels were evaluated at baseline, 2- and 3-months intervals

Quantitative polymerase chain reaction (q-PCR) was used to determine the presence and levels of P. gingivalis, A. actinomycetemcomitans, P. intermedia and T. forsythia at baseline and 3 months follow up.

HbA1c levels were evaluated at baseline, 2- and 3-months intervals

HbA1c levels were evaluated at baseline and 3-months intervals

Dr Rathna Devi Vaithilingam

University of Malaya

Patients who are planned to receive targeted agents

Patients who have received targeted therapy

Psoriasis patients without target therapy

Psoriasis

National Taiwan University Dermatology department

The Impact of Targeted Therapy on Microorganism in Patients With Psoriasis

Study 1:The sampling of eyebrow hairs and skin scales before the initiation of biologics therapy, 12 and 24 weeks after initiation of the target therapies, 12 weeks after discontinuation of target therapies. Study 2: The same above mentioned microorganisms exams were done at enrollment and repeated again 12 weeks after the discontinuation of therapies. Comparison of the prevalence of latent virus and changes from baseline in viral load of human papillomaviruses virus between psoriasis patients who are treating with and without target therapies is performed.

Study 1:The sampling of blood before the initiation of biologics therapy, 12 and 24 weeks after initiation of the target therapies, 12 weeks after discontinuation of target therapies. Study 2: The same above mentioned microorganisms exams were done at enrollment and repeated again 12 weeks after the discontinuation of therapies. Comparison of the prevalence of latent virus, and changes from baseline in viral load of cytomegalovirus between psoriasis patients who are treating with and without target therapies is performed.

Study 1:The sampling of blood before the initiation of biologics therapy, 12 and 24 weeks after initiation of the target therapies, 12 weeks after discontinuation of target therapies. Study 2: The same above mentioned microorganisms exams were done at enrollment and repeated again 12 weeks after the discontinuation of therapies. Comparison of the prevalence of latent virus, and changes from baseline in viral load of Epstein-Barr virus between psoriasis patients who are treating with and without target therapies is performed.

Study 1:The sampling of skin scales before the initiation of biologics therapy, 12 and 24 weeks after initiation of the target therapies, 12 weeks after discontinuation of target therapies. Study 2: The same above mentioned microorganisms exams were done at enrollment and repeated again 12 weeks after the discontinuation of therapies. Comparison of the prevalence of bacteria and fungi skin colonization between psoriasis patients who are treating with and without target therapies is performed.

uracil/necrosis

The Periodontal Disease and Diabetes Mellitus Interrelationship Among Adult Malaysians

The Impact of Targeted Therapy on Microorganism in Patients With Psoriasis

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