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urinary bladder neoplasms/tyrosine

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PURO Panitumumab in Combination With Gemcitabine/Cisplatin in Advanced Urothelial Cancer

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Mutation of ras oncogenes is frequently observed in human tumours and occurs in approximately 30% of all cancer types. Frequent mutation "hot spots" occur in codon 12 (glycine to valine), codon 13 (glycine to cysteine) and codon 61 (glutamine to arginine, lysine and leucine) (Bonner et al. 1993,
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