vinca difformis/sarcoma

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[The quantative measurement of cytocidal actions of antimetabolites, Vinca alcaloids and L-asparaginase against in vitro cultured Yoshida ascites sarcoma cells].

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[The cell-killing kinetics of antimetabolites and Vinca alkaloids against in vitro cultured Yoshida ascites sarcoma cells (author's transl)].

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Kaposi's sarcoma. Local management with the vinca alkaloids.

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VINCRISTINE IN THE TREATMENT OF NEOPLASTIC DISEASE.

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Seventy-eight patients with advanced malignant disease were treated with vincristine, an alkaloid derived from Vinca rosea Linn. Fifty-nine of these survived one month from the beginning of treatment and could be evaluated. Twenty made a good response, with return to activity and more than 75%

Alkaloids of Vinca rosea L. (Catharanthus roseus G. Don) XXXVI: Isolation and characterization of new dimeric alkaloids.

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In a continuing effort to study thoroughly the alkaloids of Catharanthus roseus, new dimeric alkaloids were isolated and characterized. Structures are proposed for leurocolombine and vinamidine based on UV, IR, PMR, high-resolution mass spectrometry, and CMR. Pseudovincaleukoblastine diol was

Vocal fold palsy following vinca alkaloid treatment.

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We report two patients with Hodgkin's disease on chemotherapy, one with vincristine, the other with vinblastine, who were referred to the ENT department with a vocal fold palsy. These drugs are commonly used in the treatment of haematological malignancies, and head and neck sarcomas. Examination

Preclinical antitumor activity of a new Vinca alkaloid derivative, S 12363.

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S 12363 is a new Vinca alkaloid derivative obtained by appending an optically active alpha-aminophosphonate at the C23 position of O4-deacetyl vinblastine. S 12363 was evaluated for cytotoxic and antitumor activity against a spectrum of murine and human tumors. This compound was, respectively, on

Characterization of the pharmacological antitumor effects of S 12363, a new vinca alkaloid.

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S 12363 is a new highly potent vinca alkaloid derivative characterized by the grafting of an a-aminophosphonate, bioisoster of the valine, at the C23 position of O4-deacetyl vinblastine. Using a cell image processor Samba 200 (System for Analytical Microscopic Biomedical Applications), we have

Enhanced anti-tumour effects of Vinca alkaloids given separately from cytostatic therapies.

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OBJECTIVE In polychemotherapy protocols, that is for treatment of neuroblastoma and Ewing sarcoma, Vinca alkaloids and cell cycle-arresting drugs are usually administered on the same day. Here we studied whether this combination enables the optimal antitumour effects of Vinca alkaloids to be

[Antitumor activity of navelbine (vinorelbine ditartrate), a new vinca alkaloid analog].

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The antitumor activity of navelbine (vinorelbine ditartrate, KW-2307) against murine and human transplantable tumors was compared with those of other vinca alkaloids, vindesine (VDS), vincristine (VCR) or vinblastine (VLB). KW-2307 and VDS increased the life span of mice bearing ascitic tumors (P

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