Does Fluid Replacement From Preoperative NPO Status Improve Postoperative Recovery
Kulcsszavak
Absztrakt
Leírás
Hip and knee arthroplasty are safe and reliable surgeries for the majority of patients, but a small percentage experience major complications such as myocardial infarction, deep vein thrombosis (DVT), and pulmonary embolism (PE). As these complications are related to local tissue hypoxemia and patient immobility, interventions that can improve the ability of the heart to deliver blood to the tissue and help patients mobilize earlier in their postoperative course may decrease these complications. Based on recent evidence, it has been shown that many patients are dehydrated before surgery, which can make them feel nauseous, tired, and increase their perception of pain making them less likely to mobilize. This predisposes them to DVTs, pulmonary embolism, nausea and vomiting. Peri-operative dehydration can also decrease the ability of the lungs to oxygenate the blood properly and can place additional stress on the heart, which can increase the risk of heart attacks. The specific aim is to determine if patients' peri-operative hemodynamics can be improved with preoperative administration of 2 L of lactated ringers, and consequently reduce postoperative complications and improve recovery in arthroplasty patients.
Dátumok
| Utolsó ellenőrzés: | 09/30/2017 |
| Első benyújtás: | 12/17/2015 |
| Becsült beiratkozás benyújtva: | 12/21/2015 |
| Első közzététel: | 12/22/2015 |
| Utolsó frissítés beküldve: | 10/25/2017 |
| Utolsó frissítés közzétéve: | 10/26/2017 |
| A tanulmány tényleges kezdési dátuma: | 09/30/2015 |
| Becsült elsődleges befejezési dátum: | 09/30/2016 |
| A tanulmány becsült befejezési dátuma: | 11/30/2016 |
Állapot vagy betegség
Beavatkozás / kezelés
Drug: Drug
Drug: Placebo
Fázis
Karcsoportok
| Kar | Beavatkozás / kezelés |
|---|---|
| Active Comparator: Drug Covered two liters of body temperature warmed lactated ringer's in the immediate preoperative setting of subjects undergoing total knee or total hip replacement | Drug: Drug 2L Lactated Ringer administered prior to primary knee or hip arthroplasty |
| Placebo Comparator: Placebo Covered empty bag with no hydration supplement | Drug: Placebo No additional fluids will be administered |
Jogosultsági kritériumok
| Tanulásra alkalmas korok | 18 Years Nak nek 18 Years |
| Tanulásra alkalmas nemek | All |
| Egészséges önkénteseket fogad | Igen |
| Kritériumok | Inclusion Criteria: - All patients >= 18 years of age, undergoing a total primary knee or hip arthroplasty Exclusion Criteria: - Patients weighing less than 80 kg. - Patients undergoing irrigation and debridement, explantation, or revision will not be eligible. - history of kidney disease, congestive heart failure, pulmonary edema, cirrhosis of the liver, or history of systemic fluid overloard will be excluded from the study. - No one will be excluded based on gender, ethnicity or race. |
Eredmény
Elsődleges eredménymérők
1. Reduced surgery complications [Baseline]
