Blended Oil Beneficial for Blood Lipids Management
Kulcsszavak
Absztrakt
Leírás
The primary aims of this study is to evaluate the effects of consumption of two separate blends of cooking oil, containing rice bran, flaxseed and sesame oils, for a period of 8 weeks, on blood total cholesterol, total triglycerides, low-density and high-density lipoprotein cholesterol and metabolism in borderline hyperlipidaemic, 50 to 70 years old, Chinese, male and postmenopausal female, as compared to refined olive oil. The secondary aims of the study is to evaluate the effect of the two separate blends of cooking oil on markers of cardiometabolic diseases risk (including body composition, glucose homeostasis, markers of oxidative stress and chronic inflammation) and changes in gut microbiota composition and function.
Dátumok
| Utolsó ellenőrzés: | 12/31/2019 |
| Első benyújtás: | 05/14/2019 |
| Becsült beiratkozás benyújtva: | 05/23/2019 |
| Első közzététel: | 05/27/2019 |
| Utolsó frissítés beküldve: | 01/19/2020 |
| Utolsó frissítés közzétéve: | 01/21/2020 |
| A tanulmány tényleges kezdési dátuma: | 10/31/2018 |
| Becsült elsődleges befejezési dátum: | 02/27/2021 |
| A tanulmány becsült befejezési dátuma: | 02/27/2021 |
Állapot vagy betegség
Beavatkozás / kezelés
Other: Refined olive oil (ROO)
Other: Blended Oil 1
Other: Blended Oil 2
Fázis
Karcsoportok
| Kar | Beavatkozás / kezelés |
|---|---|
| Other: Refined olive oil (ROO) Control | Other: Refined olive oil (ROO) Consumption of chicken dishes made with ROO for a period of 8 weeks |
| Experimental: Blended Oil 1 BO1, propriety blend of cooking oil containing rice bran, flaxseed and sesame oil blended at proportions different from 'Blended Oil 2 | Other: Blended Oil 1 Consumption of chicken dishes made with BO1 for a period of 8 weeks |
| Experimental: Blended Oil 2 BO2, propriety blend of cooking oil containing rice bran, flaxseed and sesame oil blended at proportions different from 'Blended Oil 1 | Other: Blended Oil 2 Consumption of chicken dishes made with BO2 for a period of 8 weeks |
Jogosultsági kritériumok
| Tanulásra alkalmas korok | 50 Years Nak nek 50 Years |
| Tanulásra alkalmas nemek | All |
| Egészséges önkénteseket fogad | Igen |
| Kritériumok | Inclusion Criteria: - Male and post-menopausal female, - Chinese ethnicity - Age ≥50 and ≤70 years - LDL cholesterol (measured) ≥3.06 mmol/l and ≤4.51 mmol/l Exclusion Criteria: - Body Mass Index (BMI) > 27.5 kg/m2. - Having allergies / intolerances to the foods in the meal accompaniments of the study - Having undergone bariatric surgery - Having fasting glucose ≥7.0 mmol/l - Having heart, kidney (nephrotic syndrome), blood or thyroid dysfunctions - History of chronic liver diseases including NAFLD, liver cirrhosis or hepatic fibrosis or having history of HIV, Hep-B or Hep-C virus - Having prescription medication or Traditional Chinese Medicine or supplements known to affect blood lipid metabolism, in the opinion of the study investigators, in the last two weeks prior to screening - Having diabetes or chronic gastrointestinal disorders - Following any special diets (for medical or aesthetic reasons) - Smoking - Having had diarrhea in the last 3 months - Having taken antibiotics in the last 3 months |
Eredmény
Elsődleges eredménymérők
1. Change from baseline serum total cholesterol [8 weeks measured every 2 weeks]
2. Change from baseline serum low density lipoprotein cholesterol [8 weeks measured every 2 weeks]
3. Change from baseline serum total high density lipoprotein cholesterol [8 weeks measured every 2 weeks]
4. Change from baseline serum total triglycerides [8 weeks measured every 2 weeks]
Másodlagos eredménymérők
1. Change from baseline of serum glucose [8 weeks measured every 2 weeks]
2. Change from baseline of serum insulin [8 weeks measured every 2 weeks]
3. Change from baseline in plasma oxidised low density lipoprotein [For 8 weeks measured every 2 weeks]
4. Change from baseline in plasma fructosamine [8 weeks measured every 2 weeks]
5. Change from baseline in plasma glycated albumin [8 weeks measured every 2 weeks]
6. Change from baseline in plasma C-reactive protein [8 weeks measured every 2 weeks]
7. Change from baseline in plasma Interleukin-6 [8 weeks measured every 2 weeks]
8. Change from baseline in plasma Interleukin-1β [8 weeks measured every 2 weeks]
9. Change from baseline in plasma Tumor necrosis factor-α [8 weeks measured every 2 weeks]
10. Change from baseline in body fat composition percentage [8 weeks]
11. Change from baseline in bone mineral density [8 weeks]
12. Change from baseline in blood pressure [8 weeks measured every 2 weeks]
13. Change from baseline in gut microflora composition [8 weeks measured on days14 and 56]
14. Change from baseline in gut microflora function [8 weeks measured on days14 and 56]
15. Change from baseline in Body weight [8 weeks measured every 2 weeks]
16. Change from baseline in segmental % body fat [8 weeks measured every 2 weeks]
17. Change in body circumference measures [8 weeks measured every 2 weeks]
