colonic polyps/nikotin

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Tobacco smoking as a risk factor for colon polyps.

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BACKGROUND Data from a cancer screening project among pattern makers were used to evaluate the association between tobacco smoking and prevalence of colon polyps. METHODS From 1981-1983, 549 White men were examined by flexible sigmoidoscopy and completed self-administered questionnaires including

Relationship between tobacco smoking and colorectal polyps.

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A prospective endoscopic screening examination of a randomized population sample of 200 men and 200 women, aged 50-59 years, enabled the differentiation between individuals with and without polyps in the rectum and sigmoid colon. Both number of years of smoking and percentage years of life with

Interaction of cigarette smoking and carcinogen-metabolizing polymorphisms in the risk of colorectal polyps.

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The causal role of cigarette smoking in the risk of colorectal neoplasm has been suggested but not established. In a case-control study including 2060 colorectal polyp patients and 3336 polyp-free controls, we evaluated 21 functional genetic variants to construct a tobacco-carcinogen-metabolizing

Predicting colorectal polyp recurrence using time-to-event analysis of medical records

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Identifying patient characteristics that influence the rate of colorectal polyp recurrence can provide important insights into which patients are at higher risk for recurrence. We used natural language processing to extract polyp morphological characteristics from 953 polyp-presenting patients'

Folate status and risk of colorectal polyps in African Americans.

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Dietary folate status appears to influence risk for colorectal cancer possibly by alterations in DNA methylation and nucleotide precursor pools. Polymorphisms (677C-->T and 1298A-->C) in methylenetetrahydrofolate reductase (MTHFR), a key enzyme in folate metabolism, determines enzyme activity. The

Epidemiology of colorectal polyps.

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The prevalence of colorectal adenomatous polyps varies widely from country to country. Among asymptomatic, average-risk patients, adenoma prevalence averages approximately 10% in sigmoidoscopy studies and more than 25% in colonoscopy studies, whereas the prevalence of colorectal cancer among these

Management of Serrated Polyps of the Colon.

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OBJECTIVE The purpose of this review is to summarize the management of serrated colorectal polyps (SPs), with a particular focus on the most common premalignant SP, sessile serrated adenoma or polyp (SSA/P). These lesions present a challenge for endoscopists with respect to detection and resection,

Lifestyle Risk Factors for Serrated Colorectal Polyps: A Systematic Review and Meta-analysis.

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Certain subsets of colorectal serrated polyps (SP) have malignant potential. We performed a systematic review and meta-analysis to investigate the association between modifiable lifestyle factors and risk for SPs. We conducted a systematic search of Medline, Embase, and Web of Science for

Muir-Torre syndrome: a case of this uncommon entity.

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A 69-year-old Hispanic woman presented for the evaluation of nodules on the head and back. In the past, she had been treated for basal cell carcinoma (BCC) of the face; the referring physician was concerned that the new lesions might also be BCC. The patient had an extensive past medical history. In

Reducing the risk of colorectal cancer by intervening in the process of carcinogenesis: a status report.

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Risk factors for colorectal cancer have been identified, and significant advances have been made in understanding the process of colorectal carcinogenesis. The transition from normal colonic mucosa to adenomatous polyp to adenocarcinoma is a gradual process involving genetic and epigenetic

Intermediate cancer biomarkers and their use in beta-carotene studies in humans.

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The most effective means of avoiding the development of squamous cell carcinomas is the elimination of risk factors such as tobacco smoke and alcohol and of exposure to occupational and dietary carcinogens. In addition, chemoprevention by micronutrients such as beta-carotene may be promising.

Postoperative morbidity and mortality among Veterans Health Administration patients undergoing surgical resection for large bowel polyps (bowel resection for polyps).

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BACKGROUND Large bowel polyps with malignant characteristics or those that are too large to remove colonoscopically may require bowel resection. METHODS We performed a retrospective review of 126 Veterans Health Administration patients who underwent elective resections for colonoscopically

Bayesian modeling of complex metabolic pathways.

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Many chronic diseases are the result of a complex sequence of biochemical reactions involving exposures to various environmental agents, metabolized by a number of different genes. Routine epidemiologic analyses of such associations have tended to rely on standard contingency table or logistic

Toxicokinetic genetics: an approach to gene-environment and gene-gene interactions in complex metabolic pathways.

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We propose an approach to modelling the joint effects of multiple genes involved in metabolic activation and detoxification of environmental exposures. A physiologically based pharmacokinetic (PBPK) model is used, in which the various person-specific metabolic rates are related to measurements of

[Risks factors for pediatric malignant liver tumors].

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OBJECTIVE Pediatric Hepatic Malignancies (PHMs) are the result of the interaction between constitutional and environmental risk factors (RFs). We review the evidence on the main RFs associated to PHMs. METHODS Systematic review of the literature published in the last 25 years on Medline, Embase,

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