otitis/hypoxia

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Effects of hypoxia-inducible factor 1α on bone conduction impairment in otitis media with effusion.

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CONCLUSIONS Elevated levels of hypoxia-inducible factor 1α (HIF-1α) in middle ear effusion may play an important role in the pathogenesis of bone conduction impairment associated with otitis media with effusion (OME). The mechanism may be related to the up-regulation of nitric oxide (NO)

Hypoxia-inducible factor and vascular endothelial growth factor pathway for the study of hypoxia in a new model of otitis media with effusion.

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The hypoxia-inducible factor and vascular endothelial growth factor (HIF-VEGF) pathway in hypoxic conditions of the middle ear due to dysfunction of the eustachian tube is still unknown, but it is considered as one pathogenetic mechanism in otitis media. This study was designed to investigate the

Myringotomy in the Junbo mouse model of chronic otitis media alleviates inflammation and cellular hypoxia.

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OBJECTIVE Ventilation of the chronically inflamed middle ear is a key outcome in functional middle ear surgery. Grommets eliminate middle ear effusion, but there is also evidence that they downregulate inflammation. The reason for this is not understood, but there is little to suggest alteration in

[Prevention of stable hypoacusis in patients with acute otitis media].

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We studied 788 patients with acute otitis media caused by cooling, common cold and made an experiment with cooling guinea pigs and white rats that developed noninvasive acute otitis media (AOM). We registered morphological and histochemical changes in the hearing organ at different stages of AOM. We

Otitis media in the Tgif knockout mouse implicates TGFβ signalling in chronic middle ear inflammatory disease.

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Otitis media with effusion (OME) is the most common cause of hearing loss in children and tympanostomy to alleviate the condition remains the commonest surgical intervention in children in the developed world. Chronic and recurrent forms of OM are known to have a very significant genetic component,

Evaluation of hypoxia in a feline model of head and neck cancer using ⁶⁴Cu-ATSM positron emission tomography/computed tomography.

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BACKGROUND Human and feline head and neck squamous cell carcinoma (HNSCC) share histology, certain molecular features, as well as locally aggressive and highly recurrent clinical behavior. In human HNSCC, the presence of significant hypoxia within these tumors is considered an important factor in

HIF-VEGF pathways are critical for chronic otitis media in Junbo and Jeff mouse mutants.

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Otitis media with effusion (OME) is the commonest cause of hearing loss in children, yet the underlying genetic pathways and mechanisms involved are incompletely understood. Ventilation of the middle ear with tympanostomy tubes is the commonest surgical procedure in children and the best treatment

The role of vascular endothelial growth factor in pediatric otitis media with effusion.

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OBJECTIVE Vascular endothelial growth factor (VEGF) is a potent and critical inducer of angiogenesis and vascular permeability, and has been shown to play an important role in inflammatory events, together with hypoxia and inflammatory cytokines. VEGF messenger ribonucleic acid (mRNA) is expressed

Adjuvant hyperbaric oxygen in malignant external otitis.

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Necrotizing invasive pseudomonal infection of the external auditory canal (malignant external otitis) is an uncommon but important disorder in the elderly. The high morbidity, and even mortality, of this disorder has been reduced by the early and intensive use of combination antipseudomonal

Transcript Analysis Reveals a Hypoxic Inflammatory Environment in Human Chronic Otitis Media With Effusion.

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Chronic otitis media with effusion (COME) is the most common cause of childhood hearing loss in the developed world. Underlying pathophysiology is not well understood, and in particular the factors that lead to the transition from acute to chronic inflammation. Here we present the first genome-wide

Otitis Media Complicated by Lateral Sinus Thrombosis and Citelli's Abscess

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Tumour spheroids are widely used as an in vitro assay for characterising the dynamics and response to treatment of different cancer cell lines. Their popularity is largely due to the reproducible manner in which spheroids grow: the diffusion of nutrients and oxygen from the surrounding culture

Measles-related hospitalizations and associated complications in jerusalem, 2018-2019.

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The 2018 measles outbreak in Israel has affected > 2000 patients in Jerusalem. The aim of the study was to describe clinical features and complications of hospitalized measles patients in Jerusalem, as related to age group and risk factors.All patients

Evaluation of the use of a questionnaire to detect hearing loss in babies in China.

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A questionnaire was used to screen hearing of 1020 babies 6-8 months in China. All babies failing the questionnaire and 10% of those who passed were tested using auditory brainstem audiometry (ABR). Babies with unilateral or bilateral hearing thresholds 30 dBnHL or more were investigated to

Perinatal risk factors in the aetiology of hearing loss in preschool children.

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In order to assess the importance of pertinent perinatal risk factors in causing hearing loss (HI), a retrospective evaluation was made of the records of 146 affected children born in the city of Göteborg between 1970 and 1979. The incidence among six-year-olds born between 1970 and 1974 was 3.8 per

Cholesterol and cholesteatoma.

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This is a histological and biochemical study of cholesterol in the middle ear in various chronic otitis media syndromes of 22 cholesteatomatous temporal bones and 52 bioptic specimens. Only three of the temporal bones and 11 surgical specimens showed cholesterol crystals, all of which were in the

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