CA-125 and Severity of Pre-Eclampsia

Although the source of CA-125 during pregnancy is the fetal chorion, amniotic fluid, and maternal decidua, the perinatal dynamics of maternal serum CA-125 requires clarification. Clinical studies of CA-125 levels and its function in hypertensive pregnant patients are limited and offered contradictory results (Cebesoy et al., 2009).

And so we investigate CA-125 in normal pregnancy and in pre-eclampsia, comparing mild and sever pre-eclampsia to determine relationship of CA-125 and severity of the disease.

Patients will be divided in three groups:

- Control: 40 normal healthy pregnant women attending the ER in labor.

- Mild pre-eclampsia: 40 patients fulfilling the following criteria.

- Blood pressure: systolic blood pressure >140 and <160 , Diastolic blood pressure >90 and <110

- Proteinuria: 300 mg (+) assessed by urine urignost 3A® (urine strips from DIALAB).

- No symptoms of severity as headache.

- Normal investigations for different organ function (as liver and kidney function).

- Severe pre-eclampsia :40 patients fulfilling anyone or more of the following criteria (The American College of Obstetricians and Gynecologists, 2010)(ACOG):

- Systolic blood pressure > 160 mmHg

- Diastolic blood pressure > 110 mmHg (on two occasions at least 6 hours apart while the patient is on bed rest)

- Proteinuria of 5000mg (5g) or higher on a 24-hour urine collection or at least 3+ on two random urine samples collected at least 4 hours apart

- Oliguria < 500 mL urine output in 24 hours

- Cerebral or visual functional disturbances (cns irritability)

- Pulmonary edema or cyanosis (not due to excessive intravenous volume replacement)

- Epigastric or right-upper quadrant abdominal pain

- Impaired liver function on laboratory analysis (elevated aspartate aminotransferase (AST), alanine amino transferase(ALT), or lactate dehydrogenase(LDH))

- Thrombocytopenia (platelet count < 150,000/uL)

- Fetal growth restriction.