Clozapine therapy in patients with neurologic illness.

OBJECTIVE

This review will analyze the use of clozapine in patients with neurologic illness.

METHODS

A review of the literature was performed. Attention is focused particularly on patients with seizure disorder, head injury, mental retardation, Parkinson's disease, Huntington's disease, tardive dyskinesia, and selected other neurological disorders.

RESULTS

This review discusses clinical difficulties/issues associated with clozapine therapy in patients with a variety of neurological disorders.

CONCLUSIONS

Although clozapine therapy should be reserved for those patients who are refractory to conventional psychotropic medications, when used appropriately it may offer a safe and effective way of improving quality of life for patients with behavioral symptoms and neurologic illness.