Termination Of Anembryonic Pregnancy
Kata kunci
Abstrak
tanggal
Terakhir Diverifikasi: | 09/30/2015 |
Pertama Dikirim: | 10/07/2015 |
Perkiraan Pendaftaran Telah Dikirim: | 10/07/2015 |
Pertama Diposting: | 10/08/2015 |
Pembaruan Terakhir Dikirim: | 10/07/2015 |
Pembaruan Terakhir Diposting: | 10/08/2015 |
Tanggal Mulai Studi Sebenarnya: | 05/31/2015 |
Perkiraan Tanggal Penyelesaian Utama: | 09/30/2015 |
Kondisi atau penyakit
Intervensi / pengobatan
Drug: Misoprostol
Drug: Misoprostol plus isosorbide mononitrate
Other: Misoprostol plus placebo
Tahap
Kelompok Lengan
Lengan | Intervensi / pengobatan |
---|---|
Active Comparator: Misoprostol plus isosorbide mononitrate this group will receive 800 µg of misoprostol (Misotac 200 µg Sigma for Pharmaceutical Industries) plus 40 mg isosorbide mononitrate (Effox 40 mg Minipharma Company) will be inserted into the posterior vaginal fornix | Drug: Misoprostol plus isosorbide mononitrate 40 mg isosorbide mononitrate (Effox 40 mg Minipharma Company) |
Active Comparator: Misoprostol plus placebo This group will receive misoprostol 800 µg plus placebo in the same site. | Other: Misoprostol plus placebo |
Kriteria kelayakan
Usia yang Layak untuk Belajar | 20 Years Untuk 20 Years |
Jenis Kelamin yang Layak untuk Belajar | Female |
Menerima Relawan Sehat | Iya |
Kriteria | Inclusion Criteria: - Maternal age ≥20years old. - No vaginal bleeding. - No dilation of internal os. - Gestational age: from 8-11weeks. - Gestational sac with a mean gestational sac diameter (MGD) greater than 25 mm and no yolk sac, or an MGD >25 mm with no embryo. Exclusion Criteria: - Patients with excessive vaginal bleeding (soaking more than a pad per day). - Patients with dilated cervix. - Patients with allergy either to misoprostol or isosorbide mononitrate. - Those who will be insisted on D and C will be excluded from the study. - Women will be excluded from the study if they are anemic (hemoglobin less than 11 g/dl). - Hemo-dynamically unstable with signs of pelvic infection and/or sepsis. - Suffering from a clotting disorder or using anticoagulants. - Women with uterine pathology such as myomas or malformation. - Women had previous caesarian section. - Asthmatic patients. |
Hasil
Ukuran Hasil Utama
1. The measurement of endometrial thickness by ultrasound in mm [6 months]
Ukuran Hasil Sekunder
1. Induction - abortion interval in hours [6 months]
2. Induction dilatation interval in hours [6 month]
3. The occurrence of sever uncontrolled lower abdominal pain by visual analogue scale [6 months]