Chinese PD-GBA Registry
Kata kunci
Abstrak
Deskripsi
Parkinson's disease (PD) is the second most common disorder among neurodegenerative diseases. GBA gene variants such as L444P can influence the risk of developing PD and these variants have the greatest impact on PD susceptibility among all the PD related gene variants yet discovered. The investigators aim to establish a database of PD with GBA variants and characterize the clinical manifestation of these patients in mainland China.
Method:
1. Peripheral blood from patients has been tested to have GBA gene variants.
2. Clinical manifestation will be measured by scales and neurological tests. Standard scales include: Unified Parkinson's Disease Rating Scale(UPDRS), Hoehn-Yahr stages, Non-Motor Symptoms Scale (NMSS), mini-mental state examination (MMSE), Parkinson disease sleep scales (PDSS), Rapid Eye Movement Sleep Behaviour Disorder Questionnaire(RBDQ-HK), Epworth Sleepiness Scale (ESS), Rome III functional constipation scale, the Scale for Outcomes in PD for Autonomic Symptoms (SCOPA-AUT), Parkinson Fatigue Scale (PFS), Cambridge-Hopkins Restless Legs Syndrome questionnaire (CHRLSq), Hyposmia rating scale(HRS), Hamilton depression scale, the 39-item Parkinson's Disease Questionnaire(PDQ-39), Freezing of gait scale(FOG), dyskinesia related scales, Wearing-off scale(WO).
3. The investigators will also exam the blood biomarkers of PD such as uric acid and peripheral inflammatory markers.
tanggal
| Terakhir Diverifikasi: | 03/31/2018 |
| Pertama Dikirim: | 04/30/2018 |
| Perkiraan Pendaftaran Telah Dikirim: | 04/30/2018 |
| Pertama Diposting: | 05/13/2018 |
| Pembaruan Terakhir Dikirim: | 05/23/2018 |
| Pembaruan Terakhir Diposting: | 05/28/2018 |
| Tanggal Mulai Studi Sebenarnya: | 01/31/2017 |
| Perkiraan Tanggal Penyelesaian Utama: | 01/31/2027 |
| Perkiraan Tanggal Penyelesaian Studi: | 01/31/2027 |
Kondisi atau penyakit
Tahap
Kriteria kelayakan
| Jenis Kelamin yang Layak untuk Belajar | All |
| Metode pengambilan sampel | Non-Probability Sample |
| Menerima Relawan Sehat | Iya |
| Kriteria | Inclusion Criteria: - Patients diagnosed with PD by the United Kingdom Parkinson's Disease Society Brain Bank clinical diagnostic criteria or other standard criteria; PD patients detected with GBA gene variants. Exclusion Criteria: - |
Hasil
Ukuran Hasil Utama
1. Database of Parkinson's disease with GBA variants [10 years]
2. Clinical feature [10 years]
