Effect of Propolis Application on Burn Healing
Kata kunci
Abstrak
tanggal
Terakhir Diverifikasi: | 01/31/2020 |
Pertama Dikirim: | 02/16/2020 |
Perkiraan Pendaftaran Telah Dikirim: | 02/17/2020 |
Pertama Diposting: | 02/19/2020 |
Pembaruan Terakhir Dikirim: | 06/29/2020 |
Pembaruan Terakhir Diposting: | 07/01/2020 |
Tanggal Mulai Studi Sebenarnya: | 08/31/2020 |
Perkiraan Tanggal Penyelesaian Utama: | 09/30/2020 |
Perkiraan Tanggal Penyelesaian Studi: | 12/31/2020 |
Kondisi atau penyakit
Intervensi / pengobatan
Biological: burn wound dressing
Tahap
Kelompok Lengan
Lengan | Intervensi / pengobatan |
---|---|
Placebo Comparator: Control group It will be accepted as the control group and 4 experimental burn wounds will be created on the back of the rats in the group and no treatment will be given. | |
Active Comparator: 1% Silver Sulfadiazine 4 experimental burn wounds will be created on the back of the rats in the group and dressing with 1% Silver Sulfadiazine will be done on the back of the rats every day for 21 days. | |
Active Comparator: %0.2 Nitrafurozon 4 experimental burn wounds will be created on the back of the rats in the group and dressing with %0.2 Nitrafurozon will be done on the back of the rats every day for 21 days. | |
Experimental: 10% Propolis 4 experimental burn wounds will be created on the back of the rats in the group and dressing with 10% Propolis will be done on the back of the rats every day for 21 days. | |
Experimental: 15% Propolis 4 experimental burn wounds will be created on the back of the rats in the group and dressing with 15% Propolis will be done on the back of the rats every day for 21 days. | |
Active Comparator: Propolis vehicle 4 experimental burn wounds will be created on the back of the rats in the group and dressing with Propolis vehicle will be done on the back of the rats every day for 21 days. |
Kriteria kelayakan
Usia yang Layak untuk Belajar | 8 Weeks Untuk 8 Weeks |
Jenis Kelamin yang Layak untuk Belajar | All |
Menerima Relawan Sehat | Iya |
Kriteria | Inclusion Criteria: - adult (8-12 weeks) - 200-300 grams - Wistar-Albino rat - with 4 second-degree superficial contact burn are at its back. Exclusion Criteria: - the death of the rat in the research process |
Hasil
Ukuran Hasil Utama
1. tumour necrosis factor-alpha, [3rd days]
2. tumour necrosis factor-alpha, [7th days]
3. interleukin-1β [3rd days]
4. interleukin-1β [7th days]
5. superoxide dismutase [3rd days]
6. superoxide dismutase [7th days]
7. malondialdehyde [3rd days]
8. malondialdehyde [7th days]
9. myeloperoxidase [3rd days]
10. myeloperoxidase [7th days]
11. hydroxyproline [14th days]
12. hydroxyproline [21st days]
13. Masson trichrome [14th days]
14. Masson trichrome [21st days]
Ukuran Hasil Sekunder
1. wound size [21 days]
2. bulla [3rd, 7th, 14th and 21st days]
3. erythema [3rd, 7th, 14th and 21st days]
4. edema [3rd, 7th, 14th and 21st days]
5. inflammatory cell infiltration [3rd, 7th, 14th and 21st days]
6. necrosis [3rd, 7th, 14th and 21st days]
7. ulceration [3rd, 7th, 14th and 21st days]
8. angiogenesis [3rd, 7th, 14th and 21st days]
9. neovascularization [3rd, 7th, 14th and 21st days]
10. fibroblast proliferation [3rd, 7th, 14th and 21st days]
11. epithelization [3rd, 7th, 14th and 21st days]
12. umber of hair follicles [3rd, 7th, 14th and 21st days]
13. damage of skin attachments [3rd, 7th, 14th and 21st days]