Gene Expression Profiles in CML Non-responders
Kata kunci
Abstrak
Deskripsi
The aim of this project is to use gene expression microarrays to detect expression profiles which may be associated with TKI resistance in order to better stratify CML patients and allow a more targeted approach to therapy. The project may also help elucidate the mechanism of resistance in those without a discernible TKD mutation. Ultimately it is hoped that this would lead to larger studies which could improve the clinical pathway for CML patients without TKD mutations.
Some previous studies have studied the gene expression profile of CML patients demonstrating resistance to TKIs, using Affymetrix arrays. However, none of these appear to have specifically investigated non-responders with and without a TKD mutation.
tanggal
| Terakhir Diverifikasi: | 12/31/2019 |
| Pertama Dikirim: | 01/02/2020 |
| Perkiraan Pendaftaran Telah Dikirim: | 01/02/2020 |
| Pertama Diposting: | 01/05/2020 |
| Pembaruan Terakhir Dikirim: | 01/02/2020 |
| Pembaruan Terakhir Diposting: | 01/05/2020 |
| Tanggal Mulai Studi Sebenarnya: | 09/30/2017 |
| Perkiraan Tanggal Penyelesaian Utama: | 05/03/2018 |
| Perkiraan Tanggal Penyelesaian Studi: | 05/03/2018 |
Kondisi atau penyakit
Intervensi / pengobatan
Genetic: Clariom
Tahap
Kriteria kelayakan
| Usia yang Layak untuk Belajar | 17 Years Untuk 17 Years |
| Jenis Kelamin yang Layak untuk Belajar | All |
| Metode pengambilan sampel | Non-Probability Sample |
| Menerima Relawan Sehat | Iya |
| Kriteria | Inclusion Criteria: - CML patients with poor response to TKIs as identified through routine clinical testing at SDGS, either with or without a tyrosine kinase domain mutation as tested for by mutational analysis. Exclusion Criteria: - Any samples that do not meet the above inclusion criteria, but particularly not CML patients with an optimal response to TKIs. |
Hasil
Ukuran Hasil Utama
1. Success identification of at least 5 markers of resistance in patients without a TKD mutation and confirmation of their expression levels using qPCR [2 months]
