Molecular Mechanisms of Raspberries Effect on Insulin Resistance and Inflammation
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StatusLengkap
Sponsor
Pennington Biomedical Research Center
Kolaborator
National Processed Raspberry Council
Louisiana State University and A&M College
UJI KLINIS: NCT04306406
BioSeek: nct04306406
Kata kunci
Abstrak
Red raspberries (Rubus idaeus) are a good source of health enhancing hydrolyzable and condensed tannins, flavonoids, anthocyanins, phenolic acids, rheosmin, potassium, carotenoids, vitamin C, and vitamin K1. Compared to other berries commonly consumed in the US, the health benefits of red raspberries to improve pre-diabetes mellitus (PDM) and type 2 diabetes have never been explored. The clinical study proposed in this project seeks to investigate the protective effect of whole red raspberries against insulin resistance, oxidative stress, and inflammation in PDM and type 2 diabetic patients. The in vitro study proposed in the project will assist in identifying the molecular mechanisms by which whole red raspberry protect islet cells against oxidative stress, insulin resistance and loss of cell function.
tanggal
| Terakhir Diverifikasi: | 02/29/2020 |
| Pertama Dikirim: | 07/29/2019 |
| Perkiraan Pendaftaran Telah Dikirim: | 03/09/2020 |
| Pertama Diposting: | 03/11/2020 |
| Pembaruan Terakhir Dikirim: | 03/09/2020 |
| Pembaruan Terakhir Diposting: | 03/11/2020 |
| Tanggal Mulai Studi Sebenarnya: | 01/06/2015 |
| Perkiraan Tanggal Penyelesaian Utama: | 01/12/2017 |
| Perkiraan Tanggal Penyelesaian Studi: | 01/12/2017 |
Kondisi atau penyakit
Inflammation
Insulin Resistance
Intervensi / pengobatan
Other: Raspberry Smoothies
Tahap
-
Kelompok Lengan
| Lengan | Intervensi / pengobatan |
|---|---|
| Other: Raspberry Smoothies Single serving smoothies drink made with red raspberries to be consumed daily for two weeks | Other: Raspberry Smoothies Red raspberry smoothies drink |
Kriteria kelayakan
| Usia yang Layak untuk Belajar | 18 Years Untuk 18 Years |
| Jenis Kelamin yang Layak untuk Belajar | All |
| Menerima Relawan Sehat | Iya |
| Kriteria | Inclusion Criteria: - type 2 diabetes Exclusion Criteria: - hypoglycemic agents - Pregnant or nursing a child - chronic medication that does not have a stable dose for greater than one month - anti-inflammatory medication - inflammatory disease |
Hasil
Ukuran Hasil Utama
1. Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) [2 weeks]
Ratio of fasting insulin and glucose
2. A high-sensitivity C-reactive protein (hs-CRP) measured in milligrams per liter [2 weeks]
Measure of systemic inflammation
Ukuran Hasil Sekunder
1. 3,4-Dihydroxyphenylacetic acid (DOPAC) measured in nanograms per milliliter [2 weeks]
Measure of systemic inflammation
