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Pilot Study on the Tolerability of Dietary Dried Plum

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StatusLengkap
Sponsor
University of California, San Francisco

Kata kunci

Abstrak

Dried plums (Prunus domestica L.) have traditionally been recognized for their health benefits related to conditions such as constipation, irregular menstrual cycles and mouth sores. This dried fruit provides high levels of fiber, vitamins and minerals. Dried plum has also been shown in animal studies to have beneficial effects on bone and can prevent the loss of bone caused by low hormone levels such as occurs after surgical removal of the ovaries. We also have shown that dried plum can prevent the loss of bone associated with aging in mice. Very few therapies for osteoporosis actually reverse bone loss and improve bone strength. The potential therapeutic value of dried plum in men and women with hormone deficiency or age-related osteoporosis is clear.

tanggal

Terakhir Diverifikasi: 01/31/2020
Pertama Dikirim: 12/15/2009
Perkiraan Pendaftaran Telah Dikirim: 12/15/2009
Pertama Diposting: 12/17/2009
Pembaruan Terakhir Dikirim: 02/25/2020
Pembaruan Terakhir Diposting: 03/01/2020
Tanggal Mulai Studi Sebenarnya: 11/30/2009
Perkiraan Tanggal Penyelesaian Utama: 08/31/2010
Perkiraan Tanggal Penyelesaian Studi: 08/31/2010

Kondisi atau penyakit

Healthy
Elderly

Intervensi / pengobatan

Dietary Supplement: dried plum

Tahap

-

Kelompok Lengan

LenganIntervensi / pengobatan
Experimental: dried plum
subjects will have 25% by weight (~ 600 kcal if eat 2500 kcal diet) of their usual diet substituted by dried plum powder
Dietary Supplement: dried plum
subjects will have 25% of their diet substituted by dried plum powder

Kriteria kelayakan

Usia yang Layak untuk Belajar 50 Years Untuk 50 Years
Jenis Kelamin yang Layak untuk BelajarAll
Menerima Relawan SehatIya
Kriteria

Inclusion Criteria:

- Age between 50 yrs and 75 yrs

- Nonsmokers

- Normal renal and hepatic function

Exclusion Criteria:

- Subjects who must follow a specific diet

- Subjects on any daily medications that affect bone health

- Subjects too heavy for the DEXA machine (weight limit 300 lbs)

- Subjects whose BMD by DEXA indicates osteoporosis

- Subjects unwilling to follow the diet specified

- Pregnant women

- Subjects who are unable to understand the consent form.

Hasil

Ukuran Hasil Utama

1. urinary calcium excretion [one month]

Ukuran Hasil Sekunder

1. ability to tolerate the diet [one month]

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