Journal of Cancer Research and Therapeutics
Cannabinoid receptor 2 is upregulated in melanoma.
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OBJECTIVE
To investigate the expression of CB 2 in normal skin, pigmented nevus, and malignant melanoma; analyze its relation with genesis; and development of malignant melanoma.
METHODS
In our study, we detected the expression of CB 2 in 20 cases of melanoma, nevus tissue, and normal skin tissues, respectively, by using immunohistochemistry, in situ hybridization, and RT-PCR. Moreover, we investigated the localization and expression of CB 2 in human melanoma cell line A375 and human immortalized keratinocyte cell line HaCaT by using immunofluorescence and western blotting.
RESULTS
Our data revealed that CB 2 is unregulated in melanoma.
CONCLUSIONS
CB 2 plays a role in the development of melanoma.
