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Zhongguo Zhongyao Zazhi 2006-Oct

[Process mechanism of Atractylodes macrocephala and conversion of sesquiterpenes].

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Wei Li
Hong-Mei Wen
Xiao-Bing Cui
Ke-Wei Zhang

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OBJECTIVE

To research the process mechanism of Atractylodes macrocephala and conversion of sesquiterpenes from it.

METHODS

The contents of atractylenolide I, II and III in the different processed herbal medicines were determined by HPLC. The conversion of the sesquiterpenes was proved by the separation of oxides of atractylone.

RESULTS

The contents of atractylenolide I and III increased after frying, and at high temperature the content of atract ylenolide III decreased. After oxidation, atractylone converted to atractylenolide I, III and biatractylenolide, and atractylenolide III converted to atractylenolide II after dehydration when heated.

CONCLUSIONS

Atractylone can convert to atractylenolides during process of A. macrocephala, and the contents of each component are related to the level of process.

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