Two New Furanoeremophilanes from Senecio santelisis.

From an Argentine collection of Senecio santelisis Phil., the new furanoeremophilanoids, (10betaH)-6beta-acetoxy-1alpha-hydroxyfuranoeremophilan-9-one (1) and (10betaH)-1alpha-hydroxy-6beta-(propanoyloxy)furanoeremophilan-9-one (2), together with the known (10alphaH)-6beta-acetoxy-1alpha-hydroxyfuranoeremophilan-9-one (3), (10alphaH)-1alpha,6beta-diacetoxyfuranoeremophilan-9-one (4), and (10alphaH)-1alpha-hydroxy-6beta-(propanoyloxy)furanoeremophilan-9-one (5) were isolated. Their structures and relative configurations were established on the basis of spectroscopic analysis. CHCl3 Extract and pure compounds were evaluated for their antifungal activity. Compound 5 exhibited remarkable mycelial growth inhibition against B. cinerea with an IC(50) value of 21.4 microg/ml.