6 hydroxyquinoline/kanker

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Derivatives of the aminated hydroxyquinoline class for treating cancers

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The present invention relates to derivatives of the aminated hydroxyquinoline class for treating cancers. A considerable arsenal of drugs used in oncology is available, alongside treatments such as radiotherapy, oncological surgery and vaccination tests, but it turns out in fact that standard

Derivatives of the aminated hydroxyquinoline class for treating cancers

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CROSS-REFERENCE TO RELATED APPLICATION This application is the U.S. national stage application of International Patent Application No. PCT/FR2008/000399, filed Mar. 25, 2008, the disclosure of which is hereby incorporated by reference in its entirety, including all figures, tables and amino acid or

Chelated 8-hydroxyquinoline and use thereof in a method of treating epithelial lesions

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BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention pertains to the field of oxinates and, particularly, to the therapeutic use of chelated metal 8-hydroxyquinolinates in the treatment of cancers, precancerous lesions, and other abnormal tissues. 2. Statement of the Problem A

8-hydroxyquinoline compounds and methods thereof

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1. FIELD OF THE INVENTION The present invention relates to 8-Hydroxyquinoline Compounds, as defined below; compositions comprising an 8-Hydroxyquinoline Compound; and methods for treating or preventing a metalloproteinase-related disorder comprising administering to a mammal in need thereof an

Hydroxyquinoline derivatives

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The invention relates to compounds of the formula I ##STR00002## in which R.sup.1, R.sup.1', R.sup.2 each, independently of one another, denote H, OH, OA, SH, SA, SOA, SO.sub.2A, Hal, NO.sub.2, NH.sub.2, NHA, NAA', A, SO.sub.2NH.sub.2, SO.sub.2NHA, SO.sub.2NAA', CONH.sub.2, CONHA, CONAA', NACOA',

Neuroprotective iron chelators and pharmaceutical compositions comprising them

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FIELD OF THE INVENTION The present invention relates to amphiphilic metal chelators that have specificity for iron and are useful for treatment of diseases, disorders and conditions by iron chelation therapy. In one aspect, the iron chelators are designed to provide desired cell membrane,

Neuroprotective iron chelators and pharmaceutical compositions comprising them

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Caspase-triggered nano-aggregation probes and methods of use

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FIELD OF THE DISCLOSURE The present disclosure relates to caspase-triggered self-assembling nano-aggregation probes for the detection of apoptotic cells and tissues. The present disclosure further relates to methods of detecting and imaging cells and tissues that are

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