Taught are derivatives of 5H-thioeno(3,4-c)pyrrole-4,6-dione, their organic, and inorganic salts, methods of synthesis of these derivatives, and their application as active pharmaceutical-ingredients useful as inhibitors of TNF.alpha., the derivative being represented by the general formula (I): ##STR00001## in which R.sup.1 represents H, C.sub.1-6alkyl, OR.sup.4, OC(O)R.sup.5, NO.sub.2, NHC(O)R.sup.6, or NR.sup.7R.sup.8; R.sup.2 represents H, a halogen, or C.sub.1-6alkyl; R.sup.3 represents H, methyl, isopropyl, allyl, benzyl, CH.sub.2CO.sub.2(C.sub.1-6alkyl), or CH.sub.2(CH.sub.2).sub.nR.sup.9; R.sup.4, R.sup.5, R.sup.6, R.sup.7, and R.sup.8 each independently and at each occurrence represents H, or C.sub.1-6alkyl; R.sup.9 represents H, C.sub.1-6alkyl, OH, OC.sub.1-6alkyl, NH.sub.2, NHC.sub.1-6alkyl, N(C.sub.1-6alkyl).sub.2, or CO.sub.2(C.sub.1-6alkyl); and n represents 1, 2, 3, or 4.

allyl/nekrosis

5H-thioeno(3,4-c)pyrrole-4,6-dione derivatives and their use as tumor necrosis factor inhibitors

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