Cardiometabolic Risk

Abdominal Obesity

Volunteers will have to consume daily 100 g of fortified biscuits and cookies instead of those usually consumed during nine weeks. The last week, volunteers will have to consume daily a fructose solution (3g/kg fat free mass)

bioactive components fortified food products intake (biscuits and cookies)

Volunteers will have to consume daily 100 g of standard biscuits and cookies instead of those usually consumed during nine weeks. The last week, volunteers will have to consume daily a fructose solution (3g/kg fat free mass)

control food products intake (biscuits and cookies)

Centre de Recherche en Nutrition Humaine Rhône-Alpes

Synergistic Innovative Functional Food Concepts to Neutralize Inflammation for Cardiometabolic Risk Prevention

Synergistic Innovative Functional Food Concepts to Neutralize Inflammation for Cardiometabolic Risk Prevention.

LBP and CD14 proteins will be measured at time 0, 120 and 300 after test meal intake

MCP-1 ( monocyte chemotactic protein-1), RANTES (Regulated on activation, normal T expressed and secreted), IFNγ (Interferon γ) , IL-6 (Interleukin 6), TNF-α (Tumor Necrosis Factor α), IL-1β (Interleukin 1β), CRPus, adiponectin will be measured at time 0 and 300 minutes after test meal intake

LPS will be measured at time 0, 60, 120, 180, 240, 300 after test meal intake

Human CVD Panel 2, Lipocalin-2/NGAL (neutrophil gelatinase-associated lipocalin), Myeloperoxidase, sICAM-1(Soluble Inter-cellular Adhesion Molecule-1), sVCAM-1(Soluble Form of Vascular Cell Adhesion Molecule 1), ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13), D-dimer, GDF-15 (Growth differentiation factor 15), Myoglobin, sP-Selectin, Serum Amyloid A will be measured at time 0 and 300 minutes after test meal intake

GSH (glutathione), GSSG (glutathione disulfide), Glutathion peroxidase/ reductase activity will be measured at time 0 and MDA (malondialdehyde) will be measured at 0 and 300 minutes after test meal intake

Body composition will be measured by BodPod technique

Plasma metabolites and hormone will be measured at time -30, 0, 15, 30, 45, 60, 90, 120, 180, 240, 300 minutes after test meal intake

fasting plasma lipids will be measured before test meal ingestion

resting metabolic rate will be measured by indirect calorimetry

substrates oxidation will be measured by indirect calorimetry after test meal intake during five hours.

gut microbiota composition will be measured by 16S RNA (ribonucleic acid) analysis

stool consistency will be measured by Bristol scale and every week during the interventional period

stool frequency will be measured by questionnaire at baseline and every week during the interventional period

Gastro intestinal symptoms will be collected by questionnaires and visual analogue scale (VAS) score (on a 90mm horizontal line; from no symptom (minimal) to serious symptom (maximum)) at baseline and every week during the interventional period

diet intake will be evaluated by a three days diet survey

comparison of fasting plasma zonulin from baseline

Comparison of polyphenols urinary concentrations from baseline

Hospices Civils de Lyon

Intervention: Oral challenge of Fructose+Glucose Beverage 1:1, 3g/kg

Adolescent Obesity

The intervention is an oral sugar challenge with blood sampling over three hours.

Fructose + Glucose Beverage

Weill Cornell Medicial College

Fructose-induced Hepatic De Novo Lipogenesis in Adolescents With Obesity

In the 2 study groups: a comparison of the increase in VLDL TG palmitate over 3 hours after ingestion of a beverage made with fructose and glucose.
after an oral challenge of fructose+glucose

In the two study groups: a comparison of other markers of carbohydrate and fatty acid metabolism (i.e. VLDL and total TG, cholesterol, apolipoprotein B, insulin, and glucose) before and after the oral sugar challenge.
2) To correlate these markers with the increase in VLDL TG %16:0.

The Rogosin Institute

Weill Medical College of Cornell University

University of Missouri-Columbia

Participant will receive a blueberry drink containing 18 g of fructose and 14 g of glucose.

Participant will receive a blueberry drink and a slice of pizza (170 grams; 22 g protein, 20 g fat and 50 g carbohydrate; 425 kCal)

Participant will receive a Soft beverage (Coca-cola containing 17,5 g fructose and 17,5 g glucose)

Participant will receive a Soft beverage and a slice of pizza (170 grams; 22 g protein, 20 g fat and 50 g carbohydrate; 425 kCal)

Participant will receive a drink containing 35 g of fructose

Participant will receive a drink containing 35 g of fructose and a slice of pizza (170 grams; 22 g protein, 20 g fat and 50 g carbohydrate; 425 kCal)

Chronic Kidney Diseases

Diabetes Mellitus, Type 2

Blueberry drink

Participant receive blueberry drink and a slice of pizza

Blueberry and pizza

Participant receive a soft beverage drink

Soft beverage

Participant receive a soft beverage drink and a slice of pizza

Soft beverage and pizza

Participant receive a drink containing fructose

Fructose

Participant receive a fructose drink and a slice of pizza

Fructose and pizza

Karolinska University Hospital

Effect of Acute Fructose Load in Human

The Effect of Acute Fructose Load in Patients With Chronic Kidney Disease and Patients With Type 2 Diabetes Compared to Healthy Subjects

Change in uric acid after intervention compared to the levels Before the intervention

Neda Rajamand Ekberg

M.D.,Ph.D

Interventional study. Participant will on sex different occasions receive drinks containing fructose (fructose drink, coca-cola or blueberry drink) with and without the addition of a high-fat meal

alpha fructose/radang

Synergistic Innovative Functional Food Concepts to Neutralize Inflammation for Cardiometabolic Risk Prevention

Fructose-induced Hepatic De Novo Lipogenesis in Adolescents With Obesity

Effect of Acute Fructose Load in Human

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