Normal saline administered intraperitoneally at defined times

Local anesthetic (ropivacaine) administered intraperitoneally at defined time intervals, similar to placebo arm

Ovarian Cancer

Experimental drug will be administered intraperitoneally

Ropivacaine

Placebo will be administered intraperitoneally

Saline Solution

Karolinska Hospital, Solna

Intra-Peritoneal Local Anaesthetics in Ovarian Cancer

A Randomised Double Blind, Multicentre Trial to Assess Time-interval Between Cytoreductive Surgery and Adjuvant Chemotherapy When Local Anaesthetic is Administered Intraperitoneally, Perioperatively

Days after surgery that the first dose of chemotherapeutic agent is given intravenously.

All complications associated with surgery and anaesthesia will be recorded

Number of patients alive at given time frame will be recorded

All study data will be retained at site of patient recruitment. Primary investigator and statistician will only have access to coded patient identity

Anil Gupta

Associate Professor

Karolinska Institutet

Karolinska University Hospital

Randomised, double blind, prospective, multicenter

Study drugs are blinded and administered perioperatively. Fully blinded for all (participants, assessors etc)

Women's age will range 25-70 years. Cases will be women diagnosed and surgically intervened of breast cancer, stages I and II.

Controls will be women surgically intervened of breast augmentation or reduction.

Breast Cancer

Unit of Mammary Pathology, General Surgery Service, University Hospital Campus de la Salud

Breast Cancer and Its Relationship With the Microbiota

Association of Breast and Gut Microbiota Dysbiosis and the Risk of Breast Cancer

Composition of bacteria, archaea, fungi and viruses present in breast tissue of women with breast cancer compared with that of women without breast cancer.

Composition of bacteria, archaea, fungi and viruses present in stool samples of women with breast cancer compared with that of women without breast cancer.

Luis Fontana

Full Professor, Ph. D., Department of Biochemistry and Molecular Biology II, School of Pharmacy, Campus de Cartuja s/n, 18071 Granada, Spain. Phone: +34958241000 Extension 20322 / +34958242318. E-mail: fontana@ugr.es

Universidad de Granada

patients were subjected to ultrasound guided SGB using 1 ml ketamine in a dose of 0.5mg/kg plus 5ml bupivacaine 0.5% in total volume 10 ml

patients were subjected to ultrasound guided SGB using 1 ml ketamine in a dose of 0.5mg/kg plus 5ml bupivacaine 0.5% in total volume 10 ml plus posterior approach shoulder injection with PRP.

Breast Neoplasms

combined platelet rich plasma and 1 ml ketamine in a dose of o.5 ml/kg plus 5ml bupivacaine 0.5% in a total volume 10 ml

Platelet rich plasma

1 ml ketamine in a dose of o.5 ml/kg plus 5ml bupivacaine 0.5% in a total volume 10 ml

ketamine and bupivacaine injection

Ultrasound Guided Stellate Ganglion Block in Postmastectomy Pain Syndrome: A Comparison of Ketamine versus Morphine as Adjuvant to Bupivacaine

Urbaniak GC, Plous S. Research randomizer. Retrieved July. 1997;7:2008.

Sweeny J, Grossman BJ. Blood collection, storage and component preparation methods. Tech Manual 14th ed Bethesda MD Am Assoc Blood Banks. 2002;955-8.

Welsh WJ. Autologous platelet gel: clinical function and usage in plastic surgery. Cosmet Derm. 2000;11:13.

MansouraU

Combined Intra-articular Shoulder Injection and Stellate Ganglion Block in Chronic Post-mastectomy Shoulder Pain

Combined Platelet Rich Plasma Intra-articular Shoulder Injection and Stellate Ganglion Block. A New Technique for Management of Chronic Post-mastectomy Shoulder Pain Syndrome

Visual analogue score (VAS) was done at rest and at shoulder movement before injection, one, two and three months after injection. VAS was explained to the patients during assessment as 0 equal no pain and 10 equal worst imaginable pain. Shoulder mobility was assessed while the patient was sitting using goniometry.

It was measured in degrees in five position (extension, flexion, and abduction, internal and external rotation) before and one month after injection.

shoulder and hand (DASH) questionnaire was done before injection, one, two and three months after injection.

Nevert Adel

Principal investigator

Mansoura University

Investigators were not allowed to know randomization codes and block size until all calculations and measurements had been entered into the database for all patients. All medical caregivers, investigators and patients were blinded to group allocation. One hour before the injection procedure of an enrolled patient, a nurse (not otherwise participating in the study) opened a sealed opaque envelope containing group allocation, and then filled the assigned drug injection for each patient according to the protocol of randomization.

Dietary supplementation with "OnLife" to improve signs and symptoms of CIPN in adult colon cancer patients who experienced a CIPN after adjuvant oxaliplatin-containing chemotherapy.

Dietary supplementation with "OnLife" to improve signs and symptoms of CIPN in adult breast cancer patients who experienced a CIPN after adjuvant paclitaxel regimen.

CIPN in Adjuvant Colon Cancer Patients

CIPN in Adjuvant Breast Cancer Patients

Daily dosing of dietary supplement OnLife

OnLife

Praxis für interdisziplinäre Onkologie & Hämatologie

Observational STudy to Evaluate the EFfectiveness of OnLife® in Improving CIPN in Patients With Colon or Breast Cancer After End of Adj. Therapy

An Observational STudy to Evaluate the EFfectiveness of OnLife® in Improving Chemotherapy-induced peripherAl NeurOpathy in Patients With Colon or Breast Cancer After End of Adjuvant Therapy

Incidence of grade 0/1/2/3/4 peripheral sensory and/ or motor neuropathy according to CTCAE v4.03 after end of adjuvant oxaliplatin-containing regimen (colon cancer) or adjuvant paclitaxel regimen (breast cancer)

Questionnaire EORTC QLQ-C30 is used to determine patients' health-related quality of life.

Questionnaire EORTC QLQ-CIPN20 is used to elicit patients' experience of symptoms and functional limitations related to CIPN.

Drug treatment of neuropathic pain is observed over the time of the OnLife® application and the month after the end of OnLife® application

amide/kanker payudara

Intra-Peritoneal Local Anaesthetics in Ovarian Cancer

Breast Cancer and Its Relationship With the Microbiota

Combined Intra-articular Shoulder Injection and Stellate Ganglion Block in Chronic Post-mastectomy Shoulder Pain

Observational STudy to Evaluate the EFfectiveness of OnLife® in Improving CIPN in Patients With Colon or Breast Cancer After End of Adj. Therapy

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