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Amide and urea derivatives as 5-HT reuptake inhibitors and as 5-HT1B/1D ligands
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The invention relates to amide and urea derivatives of the formula I
in which R.sup.1 is 3-indolyl which is unsubstituted or mono- or disubstituted by A, AO, OH, Hal, CN, NO.sub.2, NH.sub.2, NHA, NA.sub.2, COA, CONH.sub.2, CONHA, CONA.sub.2, CH.sub.2 OH, CH.sub.2 OA, CH.sub.2 NH.sub.2, CH.sub.2 NHA,
Amide compounds, their production and use
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The present invention relates to a novel amide compound having a glutamate receptor-inhibiting activity and salts thereof.
Chemical substances in spiders which paralyze the nerve of anthropodes such as insects have been isolated and their structures have been elucidated to some extent. It has been
Bicyclic amide derivatives for enhancing glutamatergic synaptic responses
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FIELD OF THE INVENTION
This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for various behaviors. Imbalances in neuronal
Bicyclic amide derivatives for enhancing glutamatergic synaptic responses
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FIELD OF THE INVENTION
This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for various behaviors. Imbalances in neuronal
Bicyclic amides for enhancing glutamatergic synaptic responses
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FIELD OF INVENTION
This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for various behaviors. These brain networks are
Ester and amide substituted (2,3-dihydro-4-(3-oxo-1-cyclohexen-1-yl)phenoxy)alkanoic acids and their salts
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BACKGROUND OF THE INVENTION
Trauma to the brain or spinal cord caused by physical forces acting on the skull or spinal column, by ischemic stroke, arrested breathing, cardiac arrest, Reye's syndrome, cerebral thrombosis, cerebral embolism, cerebral hemorrhage, encephalomyelitis, hydrocephalus,
Amides of [(5,6-dichloro-3-oxo-9-alpha-substituted-2,3,9,9-alpha-tetrahydrofluoren -7-yl-oxyl]acetic acids, and pharmaceutical compositions thereof
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BACKGROUND OF THE INVENTION
Trauma to the brain or spinal cord caused by physical forces acting on the skull or spinal column, by ischemic stroke, arrested breathing, cardiac arrest, Reye's syndrome, cerebral thrombosis, cerebral embolism, the neurological problems caused by AIDS, cerebral
Non-heterocyclic .beta.-phenyl-.alpha.-aminopropionic acid n-phenyl amides for treatment of neurotoxic injury
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FIELD OF THE INVENTION
This invention is in the field of clinical neurology and relates specifically to compounds, compositions and methods for neuroprotective purposes such as controlling brain damage which occurs during periods of anoxia or ischemia associated with stroke, cardiac arrest or
2-Alkyl/aryl sulphonyl-1,2,3,4-tetrahydro-9H-pyrido (3,4-b) indole-3-carboxylic acid esters/amides useful as antithrombotic agents
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FIELD OF THE INVENTION
The present invention relates to antithrombotic compounds 2-alkyl aryl sulphonyl-1,2,3,4-tetrahydro-9H-pyrido(3,4-b)indole-3-carboxylic acid esters/amides, pharmaceutically acceptable salts and compositions thereof useful in treatment of intravascular thrombosis such as
N-alkylpiperidinyl-4-methyl carboxylic esters/amides of condensed ring systems as 5-HT4 receptor antagonists
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This application is a 371 of PCT/GB93/02130, Oct. 14, 1993.
This invention relates to novel compounds having pharmacological activity, to a process for their preparation and to their use as pharmaceuticals.
European Journal of Pharmacology 146 (1988 ), 187-188, and Naunyn-Schmiedeberg's Arch.
Heterocycle substituted amide and sulfur amide derivatives as histone deacetylase (hdac) inhibitors
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PRIORITY CLAIM
This application is a .sctn.371 National Stage Application of PCT/GB2006/050353, filed on Oct. 26, 2006, which claims priority from GB Provisional Application Serial Number 0522130.4, filed on Oct. 31, 2005.
BACKGROUND OF THE INVENTION
In eukaryotic cells the orderly packaging of DNA
Preparation and use of 7a-amide substituted- 6,6-difluoro bicyclic himbacine derivatives as PAR-1 receptor antagonists
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FIELD OF THE INVENTION
The present invention relates to 7a-amide substituted 6,6-difluro bicyclic himbacine derivatives, which are useful as protease activated receptor-1 (PAR-1) antagonists and might be expected to be cannabinoid (CB.sub.2) receptor inhibitors. PAR-1 receptors are also known in the
Benzamide, heteroarylamide and reverse amides
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FIELD OF THE INVENTION
The present invention relates to novel benzamide, heteroarylamide and reverse amide, processes for their preparation, intermediates useful in their preparation, pharmaceutical compositions containing them, and their use in therapy. The active compounds of the present invention
Benzamide, heteroarylamide and reverse amides
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The present invention relates to novel benzamide, heteroarylamide and reverse amide, processes for their preparation, intermediates useful in their preparation, pharmaceutical compositions containing them, and their use in therapy. The active compounds of the present invention are useful in the
Heterocycle amides as cell adhesion inhibitors
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SUMMARY OF THE INVENTION
The compounds of the present invention are antagonists of the VLA-4 integrin ("very late antigen-4"; CD49d/CD29; or .alpha.4.beta.1), the .alpha.4.beta.7 integrin (LPAM-1 and .alpha.4.beta.p), and/or the .alpha.9.beta.1 integrin, thereby blocking the binding of VLA-4 to its
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