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Imidazopyridines and related derivatives as selective modulators of bradykinin B2 receptors
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FIELD OF THE INVENTION
This invention relates to certain imidazopyridines and related azacyclic derivatives which when appropriately substituted are selective modulators of Bradykinin B.sub.2 receptors. This invention also relates to pharmaceutical compositions comprising such compounds. It further
Substituted imidazoles as selective modulators of Bradykinin B2 receptors
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FIELD OF THE INVENTION
This invention relates to certain imidazoles which, when appropriately substituted, are selective modulators of Bradykinin B.sub.2 receptors (BK-2 receptors). This invention also relates to pharmaceutical compositions comprising such compounds. It further relates to the use of
Substituted tricyclic himbacine derivatives that are useful as thrombin receptor antagonists
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BACKGROUND OF THE INVENTION
Thrombin is known to have a variety of activities in different cell types and thrombin receptors are known to be present in such cell types as human platelets, vascular smooth muscle cells, endothelial cells and fibroblasts. It is therefore expected that thrombin receptor
Thrombin receptor antagonists
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BACKGROUND OF THE INVENTION
The present invention relates to substituted tricyclic thrombin receptor antagonists, pharmaceutical compositions containing them and their use in the treatment of diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia,
Thrombin receptor antagonists
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BACKGROUND OF THE INVENTION
The present invention relates to substituted tricyclic thrombin receptor antagonists, pharmaceutical compositions containing them and their use in the treatment of diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia,
Use of isatin derivatives as ion channel activating agents
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TECHNICAL FIELD
The present invention relates to ion channel activating agents. More particularly, the present invention relates to a particular class of chemical compounds that has proven useful as openers of SK.sub.Ca and IK.sub.Ca channels. In further aspects, the present invention relates to the
Metabolite of xanthine Phosphodiesterase 5 inhibitor and derivatives thereof useful for treatment of erectile dysfunction
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BACKGROUND
1. Field of the Invention
The present invention relates to a metabolite of a xanthine Phosphodiesterase type 5 ("PDE 5") inhibitor useful for treatment of erectile dysfunction, and derivatives, formulations and processes related thereto.
2. Background
U.S. patent application Ser. No.
Polynucleotides that encode the calcitonin gene-related peptide receptor coponent factor (HOUNDC44)
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FIELD OF THE INVENTION
This invention relates, in part, to newly identified polynucleotides and polypeptides; variants and derivatives of the polynucleotides and polypeptides; processes for making the polynucleotides and the polypeptides, and their variants and derivatives; agonists and antagonists
Dihydronaphthalene compounds
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FIELD OF THE INVENTION
The present invention relates to novel dihydronaphthalene compounds and processes for their preparation. The compounds of the present invention have excellent 17.alpha.-hydroxylase and/or C.sub.17-20 -lyase inhibiting activity, thromboxane A.sub.2 synthesis inhibiting
Oxazoloisoquinoline derivatives as thrombin receptor antagonists
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BACKGROUND OF THE INVENTION
The present invention relates to himbacine derivatives, which can be useful as thrombin receptor antagonists in the treatment of diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failure, cerebral ischemia,
Fused ring thrombin receptor antagonists
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BACKGROUND OF THE INVENTION
The present invention relates to himbacine derivatives, which can be useful as thrombin receptor antagonists in the treatment of diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failure, cerebral ischemia,
Fused ring thrombin receptor antagonists
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BACKGROUND OF THE INVENTION
The present invention relates to himbacine derivatives, which can be useful as thrombin receptor antagonists in the treatment of diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failure, cerebral ischemia,
Bicyclic and tricyclic derivatives as thrombin receptor antagonists
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BACKGROUND OF THE INVENTION
The present invention relates to nor-seco himbacine derivatives, which can be useful as thrombin receptor antagonists in the treatment of diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failure, cerebral
Spirocyclic thrombin receptor antagonists
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BACKGROUND OF THE INVENTION
The present invention relates to himbacine derivatives, which can be useful as thrombin receptor antagonists in the treatment of diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failure, cerebral ischemia,
Thrombin receptor antagonists
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BACKGROUND OF THE INVENTION
The present invention relates to nor-seco himbacine derivatives, which can be useful as thrombin receptor antagonists in the treatment of diseases associated with thrombosis, atherosclerosis, restenosis, hypertension, angina pectoris, arrhythmia, heart failure, cerebral
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